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Antipyrine API market price, antipyretic analgesic, cas60-80-0,Use method appearance quality standard manufacturer

Antipyrine API market price, antipyretic analgesic, cas60-80-0,Use method appearance quality standard manufacturer

Antipyrine API market price, antipyretic analgesic, cas60-80-0,Use method appearance quality standard manufacturer
Antipyrine API market price, antipyretic analgesic, cas60-80-0,Use method appearance quality standard manufacturer Antipyrine API market price, antipyretic analgesic, cas60-80-0,Use method appearance quality standard manufacturer Antipyrine API market price, antipyretic analgesic, cas60-80-0,Use method appearance quality standard manufacturer

Large Image :  Antipyrine API market price, antipyretic analgesic, cas60-80-0,Use method appearance quality standard manufacturer Get Best Price

Product Details:

Place of Origin: CHINA
Brand Name: DKY
Certification: ISO9001,GMP
Model Number: USP

Payment & Shipping Terms:

Minimum Order Quantity: KG
Price: USD 28.5/KG
Packaging Details: 25 kg cardboard drum
Delivery Time: 1days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 150T
Detailed Product Description
Purity: 99% Mf: C11H12N2O
Cas No.: 60-80-0 Package Price: USD28.5/kg
Shelf Life: 2 Years Mw: 188.23
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raw pharmaceutical materials

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raw materials for medicines

Product Name: Antipyrine
Synonyms: 1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on;1,5-Dimethyl1-2-phenyl-3-pyrazolone;phenazone(pharmaceutical);Phenozone;Phenyldimethyl isopropyl pyrazolone;Phenylon;Phenylone;Pyrazophyl
CAS: 60-80-0
MF: C11H12N2O
MW: 188.23
EINECS: 200-486-6

 

Antipyrine API market price, antipyretic analgesic, cas60-80-0,Use method appearance quality standard manufacturer 0

 

Antipyrine Usage And Synthesis
Chemical Properties White Powder
Uses Analgesic; used to test hepatic drug-metabolizing activity.
Definition ChEBI: A pyrazolone derivative that is 1,2-dihydropyrazol-3-one substituted with methyl groups at C-1 and C-5 and with a phenyl group at N-2.
dellipsoids;Aurafair;Auralgicin;Auraltone;Bajumol;Breezeazy;Calmasmin;Cetussan;Codalgin;Crema antisolar evanescente;Doleron novum;Dolo-med-much;Dol-stop;Kalopsis;Lanceotic;Lavylgan;Mig-antos;Migranin;Natt-lunedon;Neo-felsol;Orecil;Otipyrin;Otosan-sulfan;Otothricinol;Palacaine;Pasta antisola;Pomada heridas;Prednefrin;Prefrin liquifilm;Prefrin z;Priatan;Prophyllen;Remolmed;Salicopil;Sedaural;Sedonan;Shhe 21;Spalt n;Tympagesic;Visublefarite.
World Health Organization (WHO) Phenazone is a pyrazolone derivative chemically related to aminophenazone. Some regulatory authorities have imposed restrictions on its use on these grounds. However, a recent international study showed no statisticallybased evidence of an association with agranulocytosis or aplastic anaemia. Nor does it share with aminophenazone the propensity to produce potentially carcinogenic nitrosamines.
 
Purification Methods Antipyrine crystallises from EtOH/water mixture, *benzene, *benzene/pet ether or hot water (charcoal), and the crystals are dried under a vacuum.
 
Chinese aliases: Antipyrine, aminotipyrine, 1, 5-dimethyl-2-phenyl3-pyrazolone, finazone, dimethyphenylpyrazolone, English name: Antipyrine.
 

Synthetic editing

It was obtained by methylation and hydrolysis of 1-phenyl-3-methylpyrazolone-5. In a dry methylation tank, pyrazolone was added, and then dimethyl sulfate was added, and the reaction was heated to 160℃ for 6h. Then the water was heated and boiled for 2h. The methylated reactant was put into a hydrolysis tank containing sodium hydroxide solution, and was stirred and hydrolyzed for 3h at 100-110℃. The antipyrine oil layer was placed in a crystal tank, diluted with distilled water, stirred, and cooled to below 10℃. The crystals were precipitated, filtered, washed, and dried to obtain antipyrine crude. The crude product is recrystallized with distilled water and the activated carbon is decolorized. Methylation can also be done by using chloromethane or bromomethane as raw materials, and the methylation reagent can be made into a methanol solution, which is stirred slightly in excess with 1-naphthalene-3-methylpyridone. Then steam the methanol, dissolve the reactant in water, make it slightly alkaline with sodium hydroxide, extract antipyrine with benzene, recrystallize from benzene, and finally refine with activated carbon and water recrystallize. Another method is to use equal molar N, n-phenylmethylhydrazine and ethyl acetoacetate in an oil bath heated by reflux at 130-160℃. Antipyrine is extracted from a thick oily liquid with boiling water, and the water is removed by evaporation to produce crystals.

 

 

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