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API Active Pharmaceutical Ingredients Mildronate 86426-17-7 protect heart Using

API Active Pharmaceutical Ingredients Mildronate 86426-17-7 protect heart Using

API Active Pharmaceutical Ingredients Mildronate 86426-17-7 protect heart Using
API Active Pharmaceutical Ingredients Mildronate 86426-17-7 protect heart Using

Large Image :  API Active Pharmaceutical Ingredients Mildronate 86426-17-7 protect heart Using Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: 86426-17-7

Payment & Shipping Terms:

Minimum Order Quantity: 100g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 800 kgs per year
Detailed Product Description
Molecular Formula: C6H14N2O2 Molecular Weight: 146.18756
CAS No: 76144-81-5 Water Soluble: Soluble In Water; Slightly Soluble In Ether;Almost Insoluble In Acetone
Appearance: White Or White-like Crystalline Powder Melting Point: 85-90 ℃
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Mildronate 86426-17-7 Active Pharmaceutical Ingredients to protect the heart

 

Basic parameter:

1. Product name :Mildronate

2. Product nicknames :3-(2,2, 2-trimethylhydrazinium) propionatedemediation; ,2,2 Mildronate3 - (2 - Trimethylhydrazine) propionate; 3 - (2,2,2 trimethyldiazan - 2 - iumyl) propanoatedihydrate; 3 - (trimethylammonioamino) propionate; 3 - (trimethylazaniumylamino) propanoate; Kvaterin; 2 - (2 - carboxyethyl) - 1,1,1 - trimethylhydraziniumhydroxideinnersalt; 3 - (2,2,2 - trimethylhydrazine) propionate

3. Molecular formula: C6H14N2O2

4. Molecular weight: 146.18756

5. CAS no. : 76144-81-5

6. Water soluble: soluble in water; Slightly soluble in ether; Almost insoluble in acetone

7. Appearance: white or white-like crystalline powder

8. Melting point: 85-90 ℃

9. Storage conditions: Refrigerator

 

Pharmacological effects:
1, m flexor hydrazine can improve the myocardial cell energy metabolism process, inhibition of carnitine dependency fatty acid oxidation, strengthen the sugar metabolism in cells, through anaerobic glycolysis to provide energy, improve the symptoms of myocardial ischemia, hypoxia, with other drugs, such as, diuretic, etc.) vasodilators joint for the treatment of ischemic heart disease.
2. Meldonium can promote the redistribution of blood in the ischemic regions of the heart and brain, and is used for the treatment of various acute and chronic cerebral blood supply disorders.
3. By improving the fat metabolism process, the drug can improve people's working ability and relieve the psychological and physical hypertension syndrome. Athletes can improve their sports performance when taking the drug during training and competition.
4. Eliminate the functional damage to the nervous system caused by withdrawal syndrome in patients with chronic alcoholism; in addition, the drug can also improve the retinal vascular disease caused by nutritional disorders.
5. Protective effect of membrane: myocardial cell tension is caused by ischemia, which increases the breakdown of fatty acids in mitochondria, accumulation of fatty acid metabolites in cells, destruction of cell membrane devices, and increase of intracellular Ca++.
6, energy optimization: flexor m hydrazine can reduce the accumulation of long-chain acyl carnitine, which inhibits carnitine rely on fatty acid oxidation, make the anoxic myocardial energy metabolism from fatty acid oxidation into a better glucose oxidation, which has prompted glycolytic pathway of anaerobic oxidation, so this product has the anti hypoxia utility and heart activity.
7. Effects on energy metabolism enzymes: meldonium can also prevent iso-proterene-induced enhanced blood lactate dehydrogenase (myocardial specific isoenzyme) from liver dyslivability and prevent the increase of creatine phosphokinase activity.
8. Effect on carnitine excretion: other studies have shown that meldonium competitively inhibits betaine butyrate hydroxylase and blocks carnitine biosynthesis in vivo, and also competitively affects the reabsorption of carnitine in the kidney.
9. Protection of ischemic heart: in the area of myocardial ischemia, the blocked anterior descending branch not only reduces the tissue level of ATP, ADP and creatine phosphate, but also increases the tissue level of AMP and lactate, reducing the value of energy-charge potential. The results showed that meldonium could inhibit the oxidation of fatty acids and thus was very beneficial to the energy metabolism of ischemic myocardium.
 
 

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