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CAS 23593-75-1 Clotrimazole Drugs API Intermediate White Crystalline Powder

CAS 23593-75-1 Clotrimazole Drugs API Intermediate White Crystalline Powder

CAS 23593-75-1 Clotrimazole Drugs API Intermediate White Crystalline Powder
CAS 23593-75-1 Clotrimazole Drugs API Intermediate White Crystalline Powder

Large Image :  CAS 23593-75-1 Clotrimazole Drugs API Intermediate White Crystalline Powder Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Price: $280-320/kg
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 10 tons per year
Detailed Product Description
CAS No: 23593-75-1 EINECS: 245-764-8
Molecular Formula: C22H17ClN2 Molecular Weight: 344.83700
Density: 1.13 G/cm3 Melting Point: 147-149 ℃
Boiling Point: 482.3ºC At 760mmHg Flash: 245.5ºC
Index Of Refraction: 1.616 Storage Conditions: Store At RT
Vapor Pressure: 5.42E-09mmHg At 25°C Storage: Shade, Seal, Store In A Cool Place.
Appearance: White To Yellowish Crystalline Powder; Odorless, Tasteless. Solubility: Soluble In Methanol Or Trichloromethane, Soluble In Ethanol Or Acetone, Almost Insoluble In Water.
High Light:

raw pharmaceutical materials

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raw materials for medicines

 

CAS:23593-75-1 Drugs API Clotrimazole Factory Spot Supply Price Discount

 

Basic parameter:

1. Product name: clotrimazole
2. Product name: 1-[(2-chlorophenyl)diphenylmethyl]imidazole; 1 - [(2 - chlorophenyl) - diphenylmethyl] imidazole; 1 - (2 - chlorotrityl) imidazole; 1 - (o - Chlorotrityl) imidazole, 1 - (o - chlorophyll; Diphenylmethyl] 1 - [(2 - chlorophenyl) 1 h - imidazole
3. CAS no. : 23593-75-1
4. EINECS: 245-764-8
5. Molecular formula: C22H17ClN2
6. Molecular weight: 344.83700
7. Appearance and properties: odorless, white powder or colorless crystalline powder soluble in anhydrous ethanol, acetone, chloroform, almost insoluble in water. Odorless, tasteless, and rapidly decomposed in an acid solution.
8. Density: 1.13 g/cm3
9. Melting point: 147-149 ℃
10. Boiling point: 482.3 C at 760mmHg
11. Flash: DHS 245.5 C
12. Index of refraction: 1.616
13. Storage conditions: Store at RT.
14. Vapor pressure: 5.42E-09mmHg at 25°C
15. Category: antifungal agents.
16. Storage: shade, seal, store in a cool place.
17. Appearance: white to yellowish crystalline powder; Odorless, tasteless.
18. Solubility: soluble in methanol or trichloromethane, soluble in ethanol or acetone, almost insoluble in water.

 

Certificate of Analysis:

Product Name Clotrimazole Quantity 1000kgs
Batch No 20200401 Packing 25kg/Drum
MFG. Date 20200401 Exp. Date 20220401

Test Items

Specification

Test Results

Description A white or off white crystalline powder Complies
Identification IR spectrum

 

Similar to the USP Clotrimazole RS.

Complies
  TLC test Principal spot is similar to the referance solution Complies
Solubility Complies Complies

 

Related compound A

 

(o-chorophenyl)diphenylmethanol is not more than 0.2%

Complies
 

 

Each known impurity 0.2%

Complies
 

 

Each unknown impurity 0.2%

Complies
 

 

Sum of all impurities is not more than 0.5%(HPLC)

Complies
Imidazole Not more than 0.2% Complies
Loss on drying Not more than 0.5% 0.11%
Residue on ignition Not more than 0.1% 0.04%
Heavy metals Not more than 0.001% Complies
Assay

 

Not less than 98.0% and not more than 102.0%

99.8%
Residual solvent Benzene:2ppm max Complies
  Toluene:890ppm max Complies
Conclusion Up to the USP28 standard

 

Structure:

CAS 23593-75-1 Clotrimazole Drugs API Intermediate White Crystalline Powder 0

 

 

Mechanism of action:
(1) by reducing the activity of cytochrome P450, the biosynthesis of ergosterol and other sterols in the fungal cell membrane was inhibited, which damaged the fungal cell membrane and changed its permeability, leading to the loss of important substances in the cell.
(2) metrazole also inhibited the biosynthesis of triglycerides and phospholipids of fungi.
(3) the activity of oxidase and peroxidase could be inhibited, leading to the excessive accumulation of hydrogen peroxide in cells, and the degeneration of fungal subcellular structure and cell necrosis.
(4) candida albicans can inhibit its transformation from spores to invasive hyphae.
 
Purpose: broad-spectrum antifungal agent. For systemic and topical fungal infections. Antifungal agents for the treatment of epidermal and deep fungal infections.
 
 

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