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Dexamethasone 50-02-2 skin care raw materials sealed aluminum cans of white powder
Product Details:
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Detailed Product Description
| Molecular Formula: | C22H29FO5 | Molecular Weight: | 392.46100 |
|---|---|---|---|
| CAS Number: | 50-02-2 | EINECS No: | 200-003-9 |
| Appearance: | White Powder | Melting Point: | 255 ~ 264 ℃ |
| Specific Rotation: | 75（º,C=1, DIOXANE） | Solubility: | Soluble In Water, 10mg/100mL, 25℃; Ethanol, 1mg/mL. |
| Density: | 1.32g /cm3 | Boiling Point: | 568.2ºC At 760 MmHg |
| Flash: | 297.5ºC | Index Of Refraction: | 1.591 |
| High Light: | skin api,personal care raw materials |
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Dexamethasone 50-02-2 skin care raw materials sealed aluminum cans of white powder
Basic parameter:
1. Product name: dexamethasone
2. Product alias: Dexamethasone; Auxiron; Pregna - 1, 4 - diene - 3, 20 - dione,,17,21 - trihydroxy 9 - fluoro - 11-16 - methyl -, 16 (11 beta, alpha) -; Mk125; 9 a 16 - fluoro - a - methylprednisolone
3. Molecular formula: C22H29FO5
4. Molecular weight: 392.46100
5. CAS number: 50-02-2
6. EINECS no. : 200-003-9
7. Appearance: white powder
8. Melting point: 255 ~ 264 ℃
9. Specific rotation: 75 (,C=1, DIOXANE)
10. Solubility: soluble in water, 10mg/100mL, 25℃; Ethanol, 1mg/mL.
11. Density: 1.32g /cm3
12. Boiling point: 568.2℃ at 760 mmHg
13. Flash: DHS 297.5℃
14. Index of refraction: 1.591
Certificate of Analysis:
| Product Name | Dexamethasone Base | Cas No | 50-02-2 |
| Batch No | 20190803 | MFG Date | Aug.03.2019 |
| Report Date | Aug.03.2019 | Expiry Date | Jul.31. 2021 |
| Quantity | 100Kgs | Confirm | EP7.0 |
| Item | Specification | Result |
| Appearance | White or almost White, crystalline powder |
Almost White crystalline powder |
| Identification | B:IR C:TLC |
Conforms |
| Specific optical rotation |
+75°~+80° | +76.4° |
| Result substances |
Individual impurity≤0.5% | 0.37% |
| Total impurities≤1.0% | 0.85% | |
| Loss on drying | ≤0.5% | 0.20% |
| Assay | 97.0%-103.0% | 99.8% |
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Conclusion: The above product conforms to the specification of EP7.0 |
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Structure:
Pharmacological effects:
Dexamethasone (dexamethasone) is a glucocorticoid. Its derivative has the hydrogenation kedipine, prednisone and so on, its pharmacology function mainly is the anti - inflammation, anti - poison, anti - allergy, anti - rheumatism, the clinical use is widespread. It was easily absorbed from the digestive tract, and its plasma t1/2 was 190 minutes, tissue t1/2 was 3 days, and the peak blood concentration of dexamethasone sodium phosphate or dexamethasone acetate was reached at l hours and 8 hours respectively after intramuscular injection. The plasma protein binding rate of the drug was lower than that of other corticosteroid drugs. The anti-inflammatory activity of 0.75mg of the drug was equivalent to 5mg of prednisolone. Adrenocortical hormone drugs, anti-inflammatory, anti - allergic and anti - toxic than prednisone, water and sodium retention and promote potassium release is very light, can be intramuscular injection or static drop on the pituitary - adrenal inhibition of a strong.
1. Anti-inflammatory effect: it can reduce and prevent the tissue's response to inflammation, thus reducing the expression of inflammation. Hormones inhibit the aggregation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, release of lysosomal enzymes, and synthesis and release of inflammatory chemical mediators.
2. The immunosuppressive effect: including prevent or inhibit cell-mediated immune response, delayed allergic reaction, reduce T lymphocytes, monocytes, and the number of eosinophilic cells, reduce the immunoglobulin with cell surface receptor binding ability, and inhibit the synthesis and release of interleukin, thereby reducing T lymph cell to cell transformation, and reduce the expansion of the primary immune response. It can reduce the immune complex through the basement membrane and reduce the complement component and the concentration of immunoglobulin.
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