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Efavirenz 154598-52-4 Medicine Raw Material used in the fight against HIV

Efavirenz 154598-52-4 Medicine Raw Material used in the fight against HIV

Efavirenz 154598-52-4 Medicine Raw Material used in the fight against HIV
Efavirenz 154598-52-4 Medicine Raw Material used in the fight against HIV

Large Image :  Efavirenz 154598-52-4 Medicine Raw Material used in the fight against HIV Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: 154598-52-4

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Supply Ability: 500kg per year
Detailed Product Description
CAS No: 154598-52-4 Molecular Formula: C14H9ClF3NO2
Molecular Weight: 315.675 Density: 1.53 G/cm3
Boiling Point: 340.6°C At 760 MmHg Flash: 159.8 ° C
Vapor Pressure: 8.53E-05mmHg At 25°C Specific Rotation: D20 -84.7° (c = 0.005 G/ml In CH3Cl); D25 -94.1° (c = 0.300 In Methanol)
Optical Activity: [α]/D -90 To -100°, C = 1 In Methanol Water Solubility: 8mg/L(temperature Not Stated)
High Light:

raw materials for drugs

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pharmaceutical industry raw materials

Efavirenz 154598-52-4 Medicine Raw Material used in the fight against HIV

 

https://mao.ecer.com/photo/activepharmaingredient/document/17911/Analytical%20method%20of%20Efavirenz%20%28USP%29.pdf

 

Basic parameter:

1. Product name: EFAVIRENZ
2. Product aliases :(4S) -6-chloro-4 -(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl) -2h-3,1-benzoxazin-2-one; (4 s) - 6 - chloro - 4 - (cyclopropylethynyl) - 4 - (trifluoromethyl) - 1, 4 - dihydro - 2 h - 3, 1 - benzoxazin - two to one
3. CAS no. : 154598-52-4
4. Molecular formula: C14H9ClF3NO2
5. Molecular weight: 315.675
6. Density: 1.53 g/cm3
7. Boiling point: 340.6°C at 760 mmHg
8. Flash: 159.8 ° C
9. Vapor pressure: 8.53E-05mmHg at 25°C
10. Specific rotation: d20-84.7 ° (c = 0.005g /ml in CH3Cl); D25 -94.1° (c = 0.300 in methanol)
11. Optical activity: [Peter]/ d-90 to -100°, c = 1 in methanol
12. water solubility: 8mg/L(temperature not stated)
13. Appearance: white crystalline powder
 
Certificate of Analysis:
Product Efavirenz Batch no 2020.3.20
Quantity 58.4kg Manufacture Date 2020.3.20
Report Date 2020.4.2 Retest Date 2022.3.19
TEST ITEMS SPECIFICATIONS RESULTS
Appearance A White or almost white crystalline powder A white crystalline powder
Identification

IR spectra of sanple exhibit similar with standard spectra.

UV spectra of sample exhibit similar with standard spectra.

Conform
solubility

50 mgmL of Efavirenz in MethanolSolvent

Conform
water ≤0.5% 0.16%
Residue on ignition ≤0.2% 0.1%
Heavy metals ≤20ppm 10ppm
isomer ≤0.5% 0.02%
Related material
Impurity A

Impurity B

Impurity C,D,E

Impurity F

Impurity G

Impurity H

Impurity I

Impurity J

Impurity K

Impurity L

Impurity M

Impurity N

Impurity O

Impurity P

Any other individual impurity

Total impurities

 

≤0.15%

≤0.40%

≤0.10%

≤0.15%

≤0.10%

≤0.10%

≤0.25%

≤0.15%

≤0.10%

≤0.10%

≤0.10%

≤0.10%

≤0.10%

≤0.10%

≤0.10%

≤1.0%

 

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

ND

0.01%

0.02%

 

Assay(on the anhydrous solvent-free basis) 98.0%-102.0% 99.4%

Residual organic sovents

Methanol
Isopropantol
Tetrahydrofuran
Cyclohexane
Toluene

 

≤3000ppm

≤5000ppm

≤720ppm

≤3880ppm

≤890ppm

 

ND

ND

ND

ND

ND

Conclusion It complies with all the requirements of USP35  

 

Structure:

Efavirenz 154598-52-4 Medicine Raw Material used in the fight against HIV 0

 

 

Product overview:
Efavirenz is a specific drug to fight HIV. Its business name is Sustiva®. Or Stocrin® , which is a drug belonging to the NNRTI (non-nucleoside reverse transcriptase inhibitor) category, can be used in highly active anti-retroviral therapy for the treatment of a human immune virus (HIV type 1).
 
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