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Exemestane / Aromasin 107868-30-4 Steroid Hormone Powder For Women

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Exemestane / Aromasin 107868-30-4 Steroid Hormone Powder For Women

Large Image : Exemestane / Aromasin 107868-30-4 Steroid Hormone Powder For Women Get Best Price

Product Details:

Place of Origin:	hubei
Brand Name:	DKY
Certification:	COA
Model Number:	107868-30-4

Payment & Shipping Terms:

Minimum Order Quantity:	10g
Packaging Details:	1kg/bag or 100g/bag or 1kg/bag
Delivery Time:	5-7 work days
Payment Terms:	T/T, Western Union, MoneyGram
Supply Ability:	800kg per year

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Detailed Product Description

CAS No:	107868-30-4	Molecular Formula:	C20H24O2
Molecular Weight:	296.40300	Density:	1.13g /cm3
Melting Point:	155.13℃	Boiling Point:	453.7℃ At 760 MmHg
Flash:	169℃	Refractive Index:	1.572
Vapor Pressure:	2.02E-08mmHg At 25°C	Appearance:	White Or White Like Crystalline Powder; Odourless.
Solubility:	Soluble In Trichloromethane, Soluble In Ethyl Acetate, Acetone, Methanol Or Ethanol, Almost Insoluble In Water.	Contact:	8615377658509
High Light:	107868-30-4 , Exemestane Steroid Hormone Powder

Exemestane/aromasin 107868-30-4 10g/bag white powder

Basic parameter:

Product name: exemestane

Product alias:

6 - methylenandrosta - 1, 4 - diene - 3 in 2 - dione. Androsta - 1, 4 - diene - 6 - methylene - 3 in 2 - dione. 6 - METHYLENEANDROSTA - 1, 4 - DIENE - 3 in 2 - DIONE. Exemestance; 6 - Methylene - androsta - 1, 4 - diene - 3 in 2 - dione. AROMASIN; EXALAMIDE; Exemestan; 6 - methylenandrost - 1, 4 - diene - 3 in 2 - dione. Exemestane; 6 - Methyleneandrosta - 1, 4 - diene - 3 in 2 - dione.

CAS no. : 107868-30-4

Molecular formula: C20H24O2

Molecular weight: 296.40300

Density: 1.13g /cm3

Melting point: 155.13℃

Boiling point: 453.7℃ at 760 mmHg

Flash: 169℃

Refractive index: 1.572

Store in original container ina cool dark place.

Vapor pressure: 2.02E-08mmHg at 25°C

Appearance: white or white like crystalline powder; Odourless.

Solubility: soluble in trichloromethane, soluble in ethyl acetate, acetone, methanol or ethanol, almost insoluble in water.

Certificate of Analysis:

Name Of Product	Exemestane
Batch #	20191215
Mfd. Date	2019/12/15
Shelf Life	2021/12/14
Quantity	25kg

TEST ITEMS	SPECIFICATION	RESULTS
Description	White to pale yellow powder	Conform
Identification	Positive	Positive
Assay(by HPLC)	98.0~102.0%	99.05%
Absorbance(E1cm)	465~495	482.5
Melting Point	191~195°C	193.5~195.0°C
Loss On Drying	0.5%max	0.19%
Specific Rotation	+288°~ +298°	+290.2°
Residue On Ignition	0.1%max	0.03%
Related Substances	Total:1.5%max	<1.0%
	Single:0.5%max	<0.4%
Residue Solvents	0.2%max	0.1%
Heavy Metals	20PPm max	<10PPm

Conclusion

The specification conform with USP36

Product shooting:

Application:

The growth of breast cancer cells depends on the presence of estrogen, and the estrogens (estrone and estradiol) circulating in postmenopausal women are mainly converted by aromatic enzymes in the peripheral tissues to androgens (androstenedione and testosterone) in the adrenal glands and ovaries. Inhibiting estrogen production by inhibiting aromatase is an effective selective treatment for postmenopausal hormone-dependent breast cancer. Exemestane is a kind of irreversible steroidal aromatase inactivator, the structure and nature of the enzyme substrate androstenedione, similar to the pseudo substrate of aromatase, through irreversible to combine with the enzyme's active site and make its inactivation (the role is also referred to as "self-destruct inhibition"), which significantly reduce postmenopausal estrogen levels in the blood circulation, but in adrenal cortical steroids and aldehyde sterol biosynthesis has no obvious influence. Other enzymes in the steroidogenic pathway were not significantly affected when the concentration of inhibition of aromatase action was 600 times higher than that of inhibition.

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