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Flurbiprofen API /Rheumatoid arthritis drugs/CAS:5104-49-4/Analgesic and anti-inflammatory effects

Flurbiprofen API /Rheumatoid arthritis drugs/CAS:5104-49-4/Analgesic and anti-inflammatory effects

Flurbiprofen API /Rheumatoid arthritis drugs/CAS:5104-49-4/Analgesic and anti-inflammatory effects
Flurbiprofen API /Rheumatoid arthritis drugs/CAS:5104-49-4/Analgesic and anti-inflammatory effects

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Product Details:

Place of Origin: china
Brand Name: DKY
Certification: ISO9001,GMP
Model Number: Pharmaceutical grade

Payment & Shipping Terms:

Minimum Order Quantity: kg
Packaging Details: 25kg cardboard barrel
Delivery Time: 1 days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 2500kg
Detailed Product Description
Shelf Life: 2 Years Product Standard: USP Standard
Purity: 99% Cas No.: 5104-49-4
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raw materials for medicines

 
Product Name: Flurbiprofen
Synonyms: 1’-biphenyl)-4-aceticacid,2-fluoro-alpha-methyl-(;1’-biphenyl]-4-aceticacid,2-fluoro-alpha-methyl-[;2-Fluoro-a-methyl-(1,1’-biphenyl)-4-aceticacid;2-(2-Fluoro-4-biphenyl)propionicacid;2-(2-fluoro-4-biphenylyl)propionicacid;2-fluoro-alpha-methyl-4-biphenylaceticaci;bts18322;fp70
CAS: 5104-49-4
MF: C15H13FO2
MW: 244.26
EINECS: 225-827-6
 
Flurbiprofen Chemical Properties
Melting point 110-112 °C(lit.)
Boiling point 376.2±30.0 °C(Predicted)
density 1.1795 (estimate)
storage temp. Store at RT
solubility methanol: soluble50mg/mL
pka pKa 3.80(H2O) (Uncertain)
form White solid
color white to off-white
 
Anti-inflammatory analgesics Flibanserin , also known as flurbiprofen, flurbiprofen, is a potent Phenylalanine anti-inflammatory and antipyretic analgesics,it can inhibit prostaglandin synthesizing cyclooxygenase to have analgesic, anti-inflammatory and antipyretic effects. Its anti-inflammatory and analgesic effects are 250 times and 50 times of aspirin (also known as acetylsalicylic acid) . The oral absorption is rapid , peak plasma concentration achieves after 1.5 hours , half-life is 3.5 hours, it has wide tissue distribution, PPB is 99.4%, it can compete with drugs having a high plasma protein binding rate to bind plasma protein .it Metabolizes in the liver and becomes flurbiprofen hydroxy and its aldehyde acid conjugates. T1/2 is 3.5 h. Urine and fecal excretion,account for approximately 60% and 40% respectively . Age has no effect on drug metabolism. It is Mainly used for rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis. It is also used in preventing aphakic cystoid patchy edema After surgical removal of the lens, inhibiting pupillary constrictionsurgery, treatment of inflammation after cataract and trabeculoplasty argon laser eye surgery.
 
Chemical Properties White fine crystalline powder. Melting point 110111 ℃. Soluble in alcohol, ether, acetone, chlorine protection, chloroform and other organic solvents, almost insoluble in water, with a pungent odor.
Uses This product is anti-inflammatory drug for chronic arthritis and pain, inflammation of Deformation joint disease , and pain after surgery and tooth extraction. Mouse oral LD50 of 140mg/kg, rats 640-800mg/kg.
production method It is obtained by 2-fluoro-linked acetophenone through oxidation, esterification, transesterification, hydrolysis, decarboxylation reaction.
Chemical Properties White to Off-White Crystalline Solid
Uses An anti-inflammatory used as an analgesic.
Uses antiinflammatory, analgesic
Indications Flurbiprofen (Ansaid) is indicated for the treatment of rheumatoid arthritis and osteoarthritis. Its half-life, longer than that of many of the NSAIDs, allows for twice daily dosing.The most common adverse effects of flurbiprofen are similar to those of the other acidic NSAIDs. Flurbiprofen inhibits both COX isoforms about equally.
Brand name Ansaid (Pharmacia & Upjohn).
General Description Flurbiprofen (Ansaid, Ocufen, Froben), is another drug inthis class indicated for both acute and long-term managementof RA and OA but with a more complex mechanism ofaction. Unlike the other drugs in this class, it does not undergochiral inversion (i.e., the conversion of the “inactive”[R]-enantiomer to the active, [S]-enantiomer). Similar to aspirinand other salicylates, both flurbiprofen enantiomersblock COX-2 induction as well as inhibiting the nuclearfactor-κB-mediated polymorphonuclear leukocyte apoptosissignaling; therefore, both enantiomers are believed to contributeequally to its overall anti-inflammatory action.

 

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