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HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder

HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder

HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder
HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder

Large Image :  HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder Get Best Price

Product Details:

Place of Origin: hubei
Brand Name: DKY
Certification: COA
Model Number: 89778-27-8

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Packaging Details: 1kg/bag or 100g/bag
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 200kg per year
Detailed Product Description
CAS No: 89778-27-8 Molecular Formula: C26H28ClNO·C6H8O7
Molecular Weight: 598.09 EINECS No: 663-344-6
Melting Point: 160-162℃ Boiling Point: 146-148℃
Density: 1045 G/cm3 Refractive Index: 1,416-1,418
Storage Condition: Minus 20°C, Freezer Solubility: DMSO: >10mg/mL
Appearance: White Crystalline Powder Contact: 8615377658509
High Light:

89778-27-8

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Toremifene Citrate

HPLC 99% purity Toremifene citrate/Fareston 89778-27-8 white powder
 
Basic parameter:
Product name: TOREMIFENE CITRATE
Product alias:
(z) - 4 - chloro - 1, 2 - diphenyl - 1 - (4 - (2 - (n, n - dimethylamino) ethoxy) phenyl) - 1 - butene; 2 - (4 - (4 - chloro - 1, 2 - diphenyl - 1 - butenyl) phenoxy] - n, n - dimethyl - ethanamin (z) - ethanamin; 2 - hydroxy - 1, 2, 3 - propanetricarboxylate (1:1); Fareston; Fc1157a; Nk622; (z) -, 2 - [4 - (4 - chloro - 1, 2 - diphenyl - 1 - butenyl) phenoxy] - n, n - dimethyl - ethanamine 2 - hydroxy - 1, 2, 3 - propanetricarboxylate; TROPISETRON CITRATE; 2 - (4 - [(z) 1-4 - CHLORO - 1, 2 - DIPHENYL - 1 - BUTENYL] PHENOXY] - N, N - DIMETHYLETHANAMINE;
CAS no. : 89778-27-8
Molecular formula: C26H28ClNO·C6H8O7
Molecular weight: 598.09
EINECS no. : 663-344-6
Melting point: 160-162℃
Boiling point: 146-148℃
Density: 1045 g/cm3
Refractive index: 1,416-1,418
Storage condition: minus 20°C, Freezer
Solubility: DMSO: >10mg/mL
Appearance: White crystalline powder
 
Certificate of Analysis:
PRODUCT Toremifene citrate SPECIFICATION Raw material
BATCH No. 181007 EXP.DATE 2022.10
REFERENCE Export standard QUANTITY 30.4 kg
Test items Quality requirements Results
【Description White or like white crystalline powder White crystalline powder
Solubility Freely soluble in pyridine and acetic acid(100), sparingly soluble in methanol, slightly soluble in ethanol, very slightly soluble in water, and practically insoluble in diethyl ether Freely soluble in pyridine and acetic acid(100), sparingly soluble in methanol, slightly soluble in ethanol, very slightly soluble in water, and practically insoluble in diethyl ether
Melting point 159.0~163.0℃ 159.5~161.0℃
Identification    
(a)Positive reaction Must comply Complies
(b)Positive reaction Must comply Complies
(c) UV There is the strongest absorption at the wavelength of 234~238nm and 275~278nm. There is the strongest absorption at the wavelength of 237nm and 277nm.
(d) IR There is absorption at 1741, 1703, 1585, 1241 and 706cm-1 . There is absorption at 1741, 1703, 1585, 1241 and 706cm-1 .
Purity    
(a) Relative substances    
①E-isomer ≤0.5% 0,04%
②Total relative substances ≤1.0% 0.1%
(b)Heavy metals ≤10ppm <10ppm
【Loss on drying】 ≤1.0% 0.1%
Toluene ≤0.089% 0.3%
Acetone ≤0.5%  
【Residue on ignition】 ≤0.1% 0.01%
Total bacteria quantity <100 cfu/g <10 cfu/g
Mold total yeast <20 cfu/g <10 cfu/g
Escherichia coli No detected Not detected
【Assay】 ≥98.5% (Calculated by C26H28ClNO .C6H8O7) 100.0%
Conclusion: The results comply with the requirements of the export standard.

 

Product shooting:

HPLC 99% Purity Toremifene Citrate / Fareston 89778-27-8 Powder 0

 
Quick Detail:
Torremifen citrate binds to estrogen receptors and can produce estrogen-like or anti-estrogenic effects, or both, depending on the duration of treatment, animal species, sex and target organ. In general, nonsteroidal tristyrene derivatives are mainly antiestrogenic in humans and rats and estrogen-like in mice. Moderate decreases in serum total cholesterol and low density lipoprotein (LDL) were observed in postmenopausal breast cancer patients treated with torremifen. Chemicalbook and estrogen competitively bind to estrogen receptors in the cytoplasm of breast cancer cells, preventing estrogen-induced DNA synthesis and proliferation of cancer cells. The use of large doses of Torremifen citrate in some experimental tumors has shown that torremifen citrate has non-estrogen-dependent antitumor effects. The anti-breast cancer effect of Torremifen citrate is mainly the anti-estrogen effect, and there may be other anti-cancer mechanisms (change of tumor gene expression, secretion of growth factors, induction of apoptosis and influence of cell dynamics cycle).
 
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