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Ibuprofen 15687-27-1 Medicine Raw Materials Chemicals For Drugs Company
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Detailed Product Description
| CAS No: | 15687-27-1 | Molecular Formula: | C13H18O2 |
|---|---|---|---|
| Molecular Weight: | 206.28 | EINECS No: | 239-784-6 |
| Melting Point: | 77-78 ° C | Specific Rotation: | [α]D20-1～+1°(c=1,C2H5OH) |
| Boiling Point: | 157 ° C | Density: | 1.0364 |
| Refractive Index: | 1.5500 | Flash: | 9 ℃ |
| Storage Conditions: | - 20 ℃ Freezer | Solubility: | Practicallyinsolubleinwater Freelysolubleinacetone, Inmethanolandinmethylenechloride Itdissolvesindilutesolutionsofalkalihydroxidesandcarbonates. |
| High Light: | raw materials for drugs,pharmaceutical industry raw materials |
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Ibuprofen API, 15687-27-1, Drug Factory, Pharmaceutical Chemical, Drugs Company
Basic parameter:
1. Product name :Ibuprofen
2. Product nicknames :alpha-(4-isobutylphenyl)propionicacid; Alpha - (p - isobutylphenyl) propionicacid; Alpha - 2 - (p - Isobutylphenyl) propionicacid; Alpha - methyl - 4 - (2 - methylpropyl) - benzeneaceticaci; Alpha - p - isobutylphenylpropionicacid; Andran; Anflagen; Artril300
3. CAS no. : 15687-27-1
4. Molecular formula: C13H18O2
5. Molecular weight: 206.28
6. EINECS no. : 239-784-6
7. Melting point: 77-78 ° C (lit.)
8. Specific rotation: [lucume] d20-1 ~ +1°(c=1,C2H5OH)
9. Boiling point: 157 ° C (4 MMHG)
10.Density: 1.0364 (roughestimate)
11. refractive index: 1.5500 (estimate)
12. Flash: 9 ℃
13. Storage conditions: - 20 ℃ Freezer
14. Solubility: Practicallyinsolubleinwater freelysolubleinacetone, inmethanolandinmethylenechloride Itdissolvesindilutesolutionsofalkalihydroxidesandcarbonates.
Certificate of Analysis:
| Product Name | Ibuprofen(75Grade) | Batch No. | 20190719 |
| MFG. Date | 2019.07.20 | Testing Date | 2019.07.19 |
| Retest Date | 2021.07.19 | Standard | USP28 |
| ITEMS | SPECIFICATIONS | RESULTS | |
| Characteristics | White crystalline powder | Conforms | |
| Solubility | Practically insoluble in water ;very soluble in alcohol , in methanol ,in acetone, and in chloroform; slightly soluble in ethyl acetate | Conforms | |
|
Identification AIR
B.UV
C.HPLC |
a. Sample IR spectrum corresponds to that of the standard | Conforms | |
| B. Sample UV spectrum does not differ from that of the standard by more than 3.0% | Conforms | ||
| C. Retention time corresponds to that of the standard | Conforms | ||
| Water Content | not more than1.0% | 0.12% | |
| Heavy Metals | not more than0.002% | ＜0.002% | |
| Residual on Ignition | not more than0.5% | 0.02% | |
| Chromatographic Purity | 2-[3-(2-methylpropyl)phenyl]propanic acid :not more than0.15% | 0.03% | |
| 2-[4-methyl phenyl]propanic acid :not more than0.15% | 0.0% | ||
| 2-[4-ethyl phenyl]propanic acid :not more than0.15% | 0.01% | ||
| 2-[4-propylphenyl]propanic acid :not more than0.15% | 0.01% | ||
| 2-[4-butylphenyl]propanic acid :not more than0.1% | 0.0% | ||
| Any unknown impurities not more than 0.05% | 0.02% | ||
| Total impurities :not more than 0.6% | 0.07% | ||
| 4-Isobutylacetophenone | Not more than 0.1% | 0.0% | |
| Assay(dried basis) | 97.0%-103.0% | 100.1% | |
| ADDITIONAL TESTS | |||
|
Residual solvents (Petroleum ether) |
Not more than 250ppm | 79ppm | |
| Bulk Density | 0.25-0.50g/ml | 0.43g/ml | |
| Tapped density | 0.50-0.75g/ml | 0.64g/ml | |
| Median particle size | 60-90um | 89.84um | |
| Conclusion | The product meets USP28 specifications | ||
Structure:
USES:
1. It has anti-inflammatory, analgesic and antipyretic effects. Treatment of rheumatism and rheumatoid arthritis is less effective than acetylsalicylic acid and butazone. Suitable for the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosis and neuritis. It was the thirteenth most expensive drug sold in the United States in 1985.
2. Used as PG synthase inhibitor, it has the functions of antipyretic, analgesic and anti-inflammatory
3. The inhibitory activity of cyclooxygenase (COX) inhibitor on cox-1 was greater than that on cox-2.
Indications:
1, relieve rheumatoid arthritis, osteoarthritis, spondylopathy, gout arthritis, rheumatoid arthritis and other chronic arthritis of the acute onset or persistent joint swelling and pain symptoms, no etiological treatment and control of the course of disease.
2, the treatment of non-articular soft tissue rheumatic pain, such as shoulder pain, tenosynovitis, bursitis, myalgia and post-exercise injury pain.
3. Acute mild to moderate pain, such as: after surgery, after trauma, after strain, primary dysmenorrhea, toothache, headache, etc.
4, has the antipyretic effect to the adult and the child's fever.
Contact Details
WuHan Dong Kang Yuan technology co., LTD
Contact Person: Angela
Tel: 86-15377658509
Send your inquiry directly to us
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