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Indometacin API /Anti-inflammatory and analgesic/CAS:53-86-1/Pharmaceutical Raw Material

Indometacin API /Anti-inflammatory and analgesic/CAS:53-86-1/Pharmaceutical Raw Material

Indometacin API /Anti-inflammatory and analgesic/CAS:53-86-1/Pharmaceutical Raw Material
Indometacin API /Anti-inflammatory and analgesic/CAS:53-86-1/Pharmaceutical Raw Material

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Product Details:

Place of Origin: china
Brand Name: DKY
Certification: ISO,GMP
Model Number: Pharmaceutical grade

Payment & Shipping Terms:

Minimum Order Quantity: kg
Packaging Details: 25 kg cardboard drum
Delivery Time: 1days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000kg
Detailed Product Description
Appearance: White Or Yellowish Crystalline Powder Purity: 99%
Cas No.: 53-86-1 EINECS: 200-186-5
Shelf Life: 2 Years Mf: C19H16ClNO4
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raw pharmaceutical materials

Product Name: Indometacin
Synonyms: Indomethacin - CAS 53-86-1 - Calbiochem;AURORA KA-6542;INDOCIN;INDOMETACIN;INDOMETACINE;INDOMETHACIN;INDOMETHACINE;LABOTEST-BB LT00244830
CAS: 53-86-1
MF: C19H16ClNO4
MW: 357.79
EINECS: 200-186-5
 
Indometacin Chemical Properties
Melting point 155-162 °C
Boiling point 499.4±45.0 °C(Predicted)
density 1.2135 (rough estimate)
 
Uses 1.The product is anti-inflammatory, and antipyretic effect is obvious, mainly is used for salicylates to tolerance or the effect is not significant rheumatism and arthritis, ankylosing light spondylitis, osteoarthritis.
2.Non steroid anti-inflammatory analgesic
Used in Particular Diseases Acute Gouty Arthritis

 

Pharmaceutical Applications Indomethacin is a nonsteroidal anti-inflammatory agent used in pain and moderate to severe inflammation in rheumatic diseases and other musculoskeletal disorders. It is a COX (cyclooxygenase) inhibitor and therefore interrupts the production of prostaglandins.
A series of new silicon compounds, based on the structure of indomethacin, have been synthesised and are under investigation as novel anticancer agents. The carboxyl group of indomethacin was reacted with a series of amino-functionalised silanes. The resulting products have been shown to be significantly more lipophilic and more selective to COX-2. Furthermore, in vitro testing has shown an increased uptake of the new compounds at the tumour site. The silane-functionalised indomethacin derivatives exhibited a 15-fold increased antiproliferative effect when tested against pancreatic cancer .
 
 
Indometacin API /Anti-inflammatory and analgesic/CAS:53-86-1/Pharmaceutical Raw Material 0
 
Anti-inflammatory analgesic indomethacin also called indomethacin, is a function of corticoid anti-inflammatory and antipyretic and analgesic, by inhibiting cyclooxygenase reduce the synthesis of prostaglandin (PG), to prevent the formation of the nere impulses, inflammation tissue inhibiting inflammatory reaction, including inhibition of leukocyte chemotaxis and lysosomal enzyme release, etc., to produce antipyretic, analgesic and anti-inflammatory effects. Indomethacin has a strong anti-inflammatory and antipyretic effect, and its anti-inflammatory effect is 84 times stronger than that of butazone and stronger than that of hydrocortisone. Combined with glucocorticoid, aspirin and butazone, it can reduce their dosage, toxicity and side effects and improve the curative effect. Next is antipyretic action, is aminobiline 10 times; The analgesic effect is weak, and only has obvious analgesic effect on inflammatory pain, but the effect on inflammatory pain is better than that of baotexong, analgin Chemicalbook and salicylic acid. The clinic mainly is used to salicylic acid kind medicine is not easy to tolerate, or the curative effect is not obvious acute, chronic rheumatic or rheumatoid arthritis, ankylosis spondylitis, bursitis, tenosynovitis, joint bursitis, osteoarthritis, acute gout and cancer pain. In recent years, researchers have tried to use indomethacin in the treatment of biliary colic, dysmenorrhea, migraine, glomerulonephritis, polyuria, salmonella gastroenteritis, postural hypotension, bart's syndrome, etc. It can also be used to treat eye pigment membrane inflammation, keratitis, scleral inflammation, glaucoma, and cancer caused by fever or other uncontrollable fever. Dermatology is used for lupus erythematosus, behence syndrome, scleroderma, erythema tuberosity, herpes zoster, psoriasis of joint. Topical treatment of eczema, allergic dermatitis, photosensitive dermatitis, local pain.
 

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