WuHan Dong Kang Yuan Technology co., LTD

 

Integrity-based service-oriented Kangyuan products must be boutiques.

Home
Products
About Us
Factory Tour
Quality Control
Contact Us
Request A Quote
Home ProductsSkin Care Raw Materials

Isotretinoin 4759-48-2 Skin Care Raw Materials Effective for Treatment Acne

Isotretinoin 4759-48-2 Skin Care Raw Materials Effective for Treatment Acne

Isotretinoin 4759-48-2 Skin Care Raw Materials Effective for Treatment Acne
Isotretinoin 4759-48-2 Skin Care Raw Materials Effective for Treatment Acne

Large Image :  Isotretinoin 4759-48-2 Skin Care Raw Materials Effective for Treatment Acne Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: 4759-48-2

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg per year
Detailed Product Description
CAS No: 4759-48-2 Molecular Formula: C20H28O2
Molecular Weight: 300.44 EINECS No: 225-296-0
Melting Point: 172-175 °C Boiling Point: 381.66 ° C
Density: 1.0597 Index Of Refraction: 1.4800
Appearance: Yellow Or Orange - Red Crystalline Powder Or Crystals. Solubility: Insoluble In Water, Slightly Soluble In Ethanol, Very Slightly Soluble In Ether, Soluble In Chloroform.
High Light:

skin api

,

skin treatment chemicals

Isotretinoin 4759-48-2 skin care raw materials effective in the treatment of acne

 

Basic parameter:

1. Product name :Isotretinoin
2. Product nickname: TretinoinEPImpurityA; TretinoinImpurity1 (TretinoinEPImpurityA); RETINOICACID, 13 - CIS -; 3, 7 - dimethyl - 9 - (2,6,6 - trimethyl - 1 - cyclohexen - 1 - yl) - 2 - cis - 4 - trans - 6 - trans - 8 - trans - nonatetraenoicacid; 3, 7 - DIMETHYL - 9 - (2,6,6 - TRIMETHYL - 1 - CYCLOHEXEN - 1 - YL) - 2 z, 4 e, e, 6, 8 e - NONATETRANENOICACID; 13 - CIS - RETINOICACID; 13 - cis - vitaminaacid; (L) - ISOTRETINOIN
3. CAS no. : 4759-48-2
4. Molecular formula: C20H28O2
5. Molecular weight: 300.44
6. EINECS no. : 225-296-0
7. Melting point: 172-175 °C
8. Boiling point: 381.66 ° C
9. Density: 1.0597
10. Index of refraction: 1.4800
11. Storage conditions: −20°C
12. Appearance: yellow or orange - red crystalline powder or crystals.
13. Solubility: insoluble in water, slightly soluble in ethanol, very slightly soluble in ether, soluble in chloroform.
 
Certificate of Analysis:
Product Name Isotretinoin Batch No. 20190723
MFG. Date 2019.07.23 Exp Date 2021.07.22
Quantity 50 g Accord to USP38
ITEMS SPECIFICATIONS RESULTS
Description Yellow or light orange,crystalline powder Complies
Identification

A:Infrared Absorption

B:Ultraviolet Absorption

Complies

Complies

Solubility Practically insoluble in water,soluble in methylene chloride,slightly soluble in alcohol Complies
Related Substances Tretinoin ≤1.0% 0.35%
Organic volatile impurity Complies Complies
Loss on drying ≤0.5% 0.1%
Residue on ignition ≤0.1% 0.03%
Residual Solvents

Methanol≤3000ppm

Ethyl Acetate≤5000ppm

Hexane≤290ppm

Complies

Complies

Complies

Heavy metals <0.002% <0.002%
Limit of Tretinoin ≤1.0% 0.15%
Assay 98.0%-102.0% 99.69%
Conclusion The product complies with USP38

 

Structure:

Isotretinoin 4759-48-2 Skin Care Raw Materials Effective for Treatment Acne 0

 

Pharmacological effects:
Isotretinoic acid belongs to the first generation of tretinoic acid, which is A stereoisomer of all-trans tretinoic acid. Oral administration has anti-grease effect and special effect on severe acne. The mechanism of action is as follows: it can reduce the sebaceous glands, inhibit the activity of sebaceous glands, and reduce the secretion of sebaceous glands, so as to inhibit the reproduction of propionibacterium acacia acne which depends on the growth of lipid environment. Has the anti-keratinization, inhibits the epidermal cell excessive proliferation and promotes its differentiation, may reduce the hair follicle mouth and the sebaceous gland duct keratinization. Can also affect the function of monocytes and lymphocytes, inhibit the chemotaxis of neutrophils and have anti-inflammatory activity. Selectively bind the  nuclear receptor of tretinoic acid to play A therapeutic role. Inhibition of the proliferation of probacteriaceae acne at low doses and immunosuppression at high doses. Can inhibit the formation of collagenase and gelatinase in the skin, and can inhibit the activity of ornithine decarboxylase. Induction of ornithine decarboxylase can play A major role in skin mutation, so isotretinoic acid can also inhibit the occurrence of tumors. When used locally, the mechanism of action of this product is similar to that of tretinoic acid, which can induce epidermal cell proliferation, promote epidermal cell granular layer differentiation to the cuticle layer, and regulate keratinocytes in the process of abnormal keratinization of hair follicle sebum epithelium, thereby playing A therapeutic role.
 
Indications:
1. Isotretinoic acid is the first choice for refractory acne, especially for patients with severe nodular, cystic and inflammatory acne who have failed traditional treatment;
2. Generalized flat warts or verrucous epidermal dysplasia;
3. Abnormal keratotic dermatosis;
4. Cutaneous lupus erythematosus;
5. Lichen planus, sclerosing atrophic moss.

 

I am Angela
Contact Angela, you would never regret.
email: zs@dkybpc.com
Tel: +86-15377658509, you can add me on WeChat or Skype or Whatsapp if you are using that.

Contact Details
WuHan Dong Kang Yuan technology co., LTD

Contact Person: Angela

Tel: 86-15377658509

Send your inquiry directly to us