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Isotretinoin 4759-48-2 Skin Care Raw Materials Effective for Treatment Acne
Product Details:
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Detailed Product Description
| CAS No: | 4759-48-2 | Molecular Formula: | C20H28O2 |
|---|---|---|---|
| Molecular Weight: | 300.44 | EINECS No: | 225-296-0 |
| Melting Point: | 172-175 °C | Boiling Point: | 381.66 ° C |
| Density: | 1.0597 | Index Of Refraction: | 1.4800 |
| Appearance: | Yellow Or Orange - Red Crystalline Powder Or Crystals. | Solubility: | Insoluble In Water, Slightly Soluble In Ethanol, Very Slightly Soluble In Ether, Soluble In Chloroform. |
| High Light: | skin api,skin treatment chemicals |
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Isotretinoin 4759-48-2 skin care raw materials effective in the treatment of acne
Basic parameter:
1. Product name :Isotretinoin
2. Product nickname: TretinoinEPImpurityA; TretinoinImpurity1 (TretinoinEPImpurityA); RETINOICACID, 13 - CIS -; 3, 7 - dimethyl - 9 - (2,6,6 - trimethyl - 1 - cyclohexen - 1 - yl) - 2 - cis - 4 - trans - 6 - trans - 8 - trans - nonatetraenoicacid; 3, 7 - DIMETHYL - 9 - (2,6,6 - TRIMETHYL - 1 - CYCLOHEXEN - 1 - YL) - 2 z, 4 e, e, 6, 8 e - NONATETRANENOICACID; 13 - CIS - RETINOICACID; 13 - cis - vitaminaacid; (L) - ISOTRETINOIN
3. CAS no. : 4759-48-2
4. Molecular formula: C20H28O2
5. Molecular weight: 300.44
6. EINECS no. : 225-296-0
7. Melting point: 172-175 °C
8. Boiling point: 381.66 ° C
9. Density: 1.0597
10. Index of refraction: 1.4800
11. Storage conditions: −20°C
12. Appearance: yellow or orange - red crystalline powder or crystals.
13. Solubility: insoluble in water, slightly soluble in ethanol, very slightly soluble in ether, soluble in chloroform.
Certificate of Analysis:
| Product Name | Isotretinoin | Batch No. | 20190723 |
| MFG. Date | 2019.07.23 | Exp Date | 2021.07.22 |
| Quantity | 50 g | Accord to | USP38 |
| ITEMS | SPECIFICATIONS | RESULTS | |
| Description | Yellow or light orange,crystalline powder | Complies | |
| Identification |
A:Infrared Absorption B:Ultraviolet Absorption |
Complies Complies |
|
| Solubility | Practically insoluble in water,soluble in methylene chloride,slightly soluble in alcohol | Complies | |
| Related Substances | Tretinoin ≤1.0% | 0.35% | |
| Organic volatile impurity | Complies | Complies | |
| Loss on drying | ≤0.5% | 0.1% | |
| Residue on ignition | ≤0.1% | 0.03% | |
| Residual Solvents |
Methanol≤3000ppm Ethyl Acetate≤5000ppm Hexane≤290ppm |
Complies Complies Complies |
|
| Heavy metals | ＜0.002% | ＜0.002% | |
| Limit of Tretinoin | ≤1.0% | 0.15% | |
| Assay | 98.0%-102.0% | 99.69% | |
| Conclusion | The product complies with USP38 | ||
Structure:
Pharmacological effects:
Isotretinoic acid belongs to the first generation of tretinoic acid, which is A stereoisomer of all-trans tretinoic acid. Oral administration has anti-grease effect and special effect on severe acne. The mechanism of action is as follows: it can reduce the sebaceous glands, inhibit the activity of sebaceous glands, and reduce the secretion of sebaceous glands, so as to inhibit the reproduction of propionibacterium acacia acne which depends on the growth of lipid environment. Has the anti-keratinization, inhibits the epidermal cell excessive proliferation and promotes its differentiation, may reduce the hair follicle mouth and the sebaceous gland duct keratinization. Can also affect the function of monocytes and lymphocytes, inhibit the chemotaxis of neutrophils and have anti-inflammatory activity. Selectively bind the nuclear receptor of tretinoic acid to play A therapeutic role. Inhibition of the proliferation of probacteriaceae acne at low doses and immunosuppression at high doses. Can inhibit the formation of collagenase and gelatinase in the skin, and can inhibit the activity of ornithine decarboxylase. Induction of ornithine decarboxylase can play A major role in skin mutation, so isotretinoic acid can also inhibit the occurrence of tumors. When used locally, the mechanism of action of this product is similar to that of tretinoic acid, which can induce epidermal cell proliferation, promote epidermal cell granular layer differentiation to the cuticle layer, and regulate keratinocytes in the process of abnormal keratinization of hair follicle sebum epithelium, thereby playing A therapeutic role.
Indications:
1. Isotretinoic acid is the first choice for refractory acne, especially for patients with severe nodular, cystic and inflammatory acne who have failed traditional treatment;
2. Generalized flat warts or verrucous epidermal dysplasia;
3. Abnormal keratotic dermatosis;
4. Cutaneous lupus erythematosus;
5. Lichen planus, sclerosing atrophic moss.
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