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Levonorgestrel 797-63-7 Estrogen Hormone Raw Material Pregnancy Hormone Drugs

Levonorgestrel 797-63-7 Estrogen Hormone Raw Material Pregnancy Hormone Drugs

Levonorgestrel 797-63-7 Estrogen Hormone Raw Material Pregnancy Hormone Drugs
Levonorgestrel 797-63-7 Estrogen Hormone Raw Material Pregnancy Hormone Drugs

Large Image :  Levonorgestrel 797-63-7 Estrogen Hormone Raw Material Pregnancy Hormone Drugs Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: 797-63-7

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 800kg per year
Detailed Product Description
CAS No: 797-63-7 Molecular Formula: C21H28O2
Molecular Weight: 312.44600 Density: 1.13g /cm
Melting Point: 206 ℃ Boiling Point: 459.1 ℃at 760 MmHg
Flash Point: 195.4 ℃ Refractive Index: 1.571
Storage Condition: 2-8 ℃ Heavy Metal: ≤0.03.0 PPM
Solubility: Practicallyinsolubleinwater, Sparingly Soluble In Methylenechloride, Slightly Soluble In Ethanol (96 Percent). Appearance: White Or White-like Crystalline Powder; Odorless, Tasteless. Storage: Store In A Cool, Dry Place, Close And Out Of Light.
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female estrogen raw material

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Levonorgestrel 797-63-7 estrogen hormone raw material Pregnancy hormone drugs
 
Basic parameter:
1. Product name: Levonorgestrel
2. Product alias: postinor; Microluton; Norgeston; Levonorgestrel. [3 h] - Levonorgestrel; [the 18th and 19th - Dinorpregn - 4 - en - 20 - yn - 3 - one - 13 - baton rouge - 17 - hydroxy - (17. Alpha.) - (-) -]
3. CAS no. : 797-63-7
4. Molecular formula: C21H28O2
5. Molecular weight: 312.44600
6. Density: 1.13g /cm
7. Melting point: 206 ℃
8. Boiling point: 459.1 ℃at 760 mmHg
9. Flash point: 195.4 ℃
10. Refractive index: 1.571 
11. Storage condition: 2-8 ℃
12. Heavy metal: ≤0.03.0 PPM
13. Solubility: Practically in soluble in water, sparingly soluble in methylenechloride, slightly soluble in ethanol (96 percent).
14. Appearance: white or white-like crystalline powder; Odorless, tasteless.
15. Storage: store in a cool, dry place, close and out of light.
 
Certificate of Analysis:

Product Name

Levonorgestrel

Batch Size

100g

Manufacturing Date

2019.12.16

Batch No.

20191216

Expiry Date

2023.06.15

Report Date

2019.12.23

Reference Standard

USP 32

Packing

1kg

TEST

ACCEPTANCECRITERIONS

RESULTS

Identification

TLC

Positive

 

UV spectrum

Positive

 

IR spectrum

Positive

Characteristics

White or yellowishcrystallineowder

conform

Melting point

232 ~ 239℃

234~237.5℃

Loss on drying

≤0.5%

0.21%

Specific rotation

–30~ –35°

-33°

Limit of ethinyl group

7.81~8.18%

7.98%

Residual Solvents

ethanol≤0.5%

Pass

Other sterold

sum of the impurities≤2.0%

single impurity ≤0.5%

Pass

Residue on ignition

≤0.3%

0.19%

Assay

98.0~102.0%

99.16%

Conclusion

This batch complies with USP 32

 
 

Structure::

Levonorgestrel 797-63-7 Estrogen Hormone Raw Material Pregnancy Hormone Drugs 0
Pharmacological effects:
Levonorgestrel (LNG) is a fully synthesized potent progesterone, which is the optical active agent of racogonorgestrel. The activity of levonorgestrel is 1 times stronger than that of norethinnes, and about 100 times as strong as that of norethinnes. For this reason, the dose of enorgestrel can be halved and the adverse reactions reduced. Levonorgestrel mainly ACTS on the hypothalamus and pituitary gland, causing the peak of FSH and LH levels in the middle menstrual period to significantly reduce or disappear, and the ovaries do not ovulate. It has obvious anti-estrogen activity, which is about 10 times stronger than norethinnes, with almost no estrogen activity. It thickens the cervical mucus and prevents sperm from penetrating. The transformation of endometrium showed strong progesterone activity, which could make the endometrium thin, the endometrial epithelial cells were low columnar, and the secretion function was not good, which was not conducive to egg implantation. LNG also has certain androgen activity and protein assimilation, which can inhibit ovulation by oral or subcutaneous injection.
 
Drug interactions:
(1) . influence the contraceptive effect of drugs;
①. antibiotics inhibit the growth of intestinal bacteria, reduce the decomposition of hormone binding substances, reduce intestinal liver circulation;
② . drugs that induce liver drug enzymes, such as rifampicin, hypnotics and anticonvulsants, antipyretic analgesics;
③. Tricyclic antidepressants compete with this product in the liver for common metabolic enzymes.
(2).  combined with the contraceptive pill, the effect of the drug affected;
①. The antihypertensive effect of antihypertensive drugs is reduced;
②. The anticoagulant effect of anticoagulants is reduced;
③. the efficacy of hypoglycemic agents (such as insulin and oral hypoglycemic agents) in controlling diabetes is reduced;
④. The effect of tricyclic antidepressants was enhanced.
 
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