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Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity

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Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity

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Product Details:

Place of Origin:	China
Brand Name:	DKY
Model Number:	79794-75-5

Payment & Shipping Terms:

Minimum Order Quantity:	100g
Packaging Details:	1kg/bag or 25kg/drum
Delivery Time:	5-7 work days
Payment Terms:	T/T, Western Union, MoneyGram
Supply Ability:	1000kg per year

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Detailed Product Description

CAS No:	79794-75-5	Molecular Formula:	C22H23ClN2O2
Molecular Weight:	382.88300	Melting Point:	134-136 ° C
Density:	1.261 G/cm3	Boiling Point:	531.3 Cat 760 MmHg
Flash:	275.1ºC	Stability:	Stable, But May Be Thermally Sensitive - Refrigerated. Incompatible With Strong Oxidants.
Storage Conditions:	2-8ºC	Appearance:	White Or White-like Crystalline Powder, Odorless
Solubility:	Soluble In Methanol, Ethanol Or Acetone; Slightly Dissolved In 0.1mol/L Hydrochloric Acid Solution; It's Almost Insoluble In Water.	Class:	Antihistamines.
High Light:	pharma raw material , raw pharmaceutical materials

Loratadine 79794-75-5 Pharmaceutical Raw Material antihistamines

Basic parameter:

1. Product name: Loratadine

2. Product alias: Claritine; Loranox; CLARATYNE; Doesn; Tadine; Clarityne; Claritine

3. CAS no. : 79794-75-5

4. Molecular formula: C22H23ClN2O2

5. Molecular weight: 382.88300

6. Melting point: 133 ~ 137℃

7. Density: 1.261 g/cm3

8. Melting point: 134-136 ° C

9. Boiling point: 531.3 Cat 760 mmHg

10. Flash: DHS 275.1 C

11. Stability: stable, but may be thermally sensitive - refrigerated. Incompatible with strong oxidants.

12. Storage conditions: 2-8 C

13. Appearance: white or white-like crystalline powder, odorless;

14. Solubility: soluble in methanol, ethanol or acetone; Slightly dissolved in 0.1mol/L hydrochloric acid solution; It's almost insoluble in water.

15. Class: antihistamines.

16. Storage: shading and sealing.

Certificate of Analysis:

Product

LORATADINE

batch No.	190818	Mfg. date	2019.08.18
Approval Date	2019.08.18	Exp. date	2021.08.17

Tests	Results	Specifications
Appearance	Complies	White or off white crystalline powder
Solubility	Complies	Freely soluble in acetone,in chloroform,in methanol and in toluene;insoluble in water.
Identification	Complies	A. By IR absorption, To match with working standard.
	Complies	B. The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
Melting Point	133.5℃～136.3℃	132℃~ 137℃
Loss on drying	0.12%	≤0.5%
Residue on ignitio	0.03%	≤0.1%

Related substance

Related compound A	Not Detected	≤ 0.1%
Related compound B	Not Detected	≤ 0.1%
Each individual unknown impurity	0.03%	≤ 0.1%
Total impurities	0.12%	≤ 0.3%
Heavy metal	＜10ppm	≤10ppm
Residual solvent	Not Detected	Isopropyl ether≤0.5%
	Not Detected	Ethyl acetate≤0.5%
	Not Detected	Toluene≤0.089%
Assay	99.74%	98.5%-101.0%

Conclusion: the material comform to the USP36

Structure:

Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity 0

Pharmacological effects:

Piperidine antihistamines, derivatives of azatadine, selectively antagonize peripheral histamine H1 receptors. Its antihistamine action effect is fast, strong, lasting. Its effect is stronger than astimidazole and terfenadine. This product has no sedative effect and has no anti - muscarinoid choline effect. No enhancement to ethanol. Absorption is rapid and good after oral administration. The peak time of serum concentration tmax was 1.5 hours. The binding rate to plasma protein was 98%. Most of it is metabolized in the liver, and the metabolite decarboxylethoxychloratadine still has antihistamine activity. The product and its metabolites were excreted in urine and feces, and t1/2 lasted about 20 hours. Neither the product nor its metabolites can easily pass the blood-brain barrier, but can appear in milk.

USES:

Antihistamine has high selectivity, strong effect and long time for peripheral H1 receptor. It is a long-acting tricyclic antihistamine, which competitively inhibits the histamine H1 receptor and inhibits the allergic symptoms caused by histamine. There was no significant anticholine and central inhibitory effect. Used to relieve symptoms associated with allergic rhinitis, as well as chronic urticaria and other symptoms of allergic skin diseases.

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