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Medicine Raw Materials Paracetamol API 103-90-2 Used As Antipyretic Analgesics

Medicine Raw Materials Paracetamol API 103-90-2 Used As Antipyretic Analgesics

Medicine Raw Materials Paracetamol API 103-90-2 Used As Antipyretic Analgesics
Medicine Raw Materials Paracetamol API 103-90-2 Used As Antipyretic Analgesics Medicine Raw Materials Paracetamol API 103-90-2 Used As Antipyretic Analgesics Medicine Raw Materials Paracetamol API 103-90-2 Used As Antipyretic Analgesics

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Product Details:

Place of Origin: CHINA
Brand Name: DKY
Certification: ISO,GMP
Model Number: USP,CP,EP

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Price: USD 12/KG
Packaging Details: 25 kg cardboard drum
Delivery Time: 1DAYS
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 200T
Detailed Product Description
English Name: Paracetamol Purity: 99%
Cas No.: 103-90-2 Einecs No.: 203-157-5
Mf: C8H9NO2 The Alias: 4-Acetamidophenol
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Product Name: Paracetamol
Synonyms: 4-Acetamidophenol, 98.5%, a selective cyclooxygenase-2 inhibitor;purexiyongh;4'-HYDROXYACETANILIDE;4-HYDROXYACETANILIDE;4-(ACETYLAMINO)PHENOL;ACETAMINOPHEN;ACETYL-P-AMINOPHENOL;AKOS BBS-00008094
CAS: 103-90-2
MF: C8H9NO2
MW: 151.16
EINECS: 203-157-5

 

General Description Odorless white crystalline solid. Bitter taste. pH (saturated aqueous solution) about 6.
Air & Water Reactions Slightly soluble in water.
Reactivity Profile 4-Acetamidophenol is sensitive to light. Incompatible with strong oxidizers.
 
Antipyretic analgesic The chemiacal name of 4-acetaminophen is N-(4-hydroxy phenyl) acetamide and the trade name is paracetamol belonging to acetanilide antipyretic analgesics. It was first synthesized by Morse in 1878 and first used in clinic by VonMering in 1893. It has become an over the counter drug in the USA since 1955 and our country started production at the end of the 1950’s. 4-acetaminophen is a white crystalline or a crystalline powder in appearance with melting point from 168℃ to 172℃, odorless, slightly bitter taste, freely soluble in hot water or ethanol, dissolved in acetone, practically insoluble in cold water and petroleum ether. It is stable below 45℃ but will be hydrolyzed into p-aminophenol when exposed to humid air, then oxidized further. The color grades gradually from pink to brown then to black, so it should be sealed and stored in a cool and dry place.

 

 

Medicine Raw Materials Paracetamol API 103-90-2 Used As Antipyretic Analgesics 0

This product is used as antipyretic analgesics. It has the antipyretic activity by means of mediated peripheral vasodilation and perspiration caused by inhibiting the cyclooxygenase which selectively inhibiting the synthesis of hypothalamic thermoregulation prostaglandins, and its strength of antipyretic effect is similar to aspirin. As a peripheral analgesic, it can produce analgesic effect by inhibiting the synthesis and release of prostaglandins and increasing pain threshold. However, its action is weaker than aspirin and it is only effective for mild to moderate pain. There is no obvious anti-inflammation effect.

 

 

Production Produced by acetylation of p-aminophenol. Method 1: add p-aminophenol into dilute acetic acid, then add glacial acetic acid, heat up to 150℃and react for 7h, add acetic anhydride and react for 2h, check the end point and cool to 25℃ after the acceptance, shake it and filter, water until no acetic acid flavor exists, dry to get crude products. Method 2: distill p-aminophenol, acetic acid and acid industrial containing more than 50% acid together, the speed of distilling dilute acid for is 1/10 of the total distillate in one hour, check the residue of p-aminophenol less than 2.5% aminophenol by sampling inspection when inner temperature rises up to 130℃, add dilute acid (content of more than 50%), cool to get crystallization. After shaking and filter, first use a small amount of dilute acid to wash, and then use a large number of water till filtrate is near colourless to get crude products. The yield of method 1 is 90%, but the yield of method 2 is 90-95%. Refining methods: add the crude product when the water is heated to near boiling. Heat up to the total dissolution, add activated carbon soaked in water, use dilute acetic acid to adjust till pH=4.2-4.6, boil for 10min. Filter press, add a small amount of sodium bisulfite into the filtrate. Cool to below 20℃, separate crystals out. After shaking and filter, wash and dry to get active ingredients, paracetamol finished products. Other methods of production are as followed: (1) p-nitrophenol is reduced by zinc in acetic acid, and acetaminophen is obtained by acetylation at the same time; (2) put the hydrazone generated from p-hydroxyacetophenone in acid solution containing sulfuric acid, and then add sodium nitrite to get acetaminophen by renversement.

 

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