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Medroxyprogesterone 17-acetate 71-58-9 estrogen hormone raw material USP 1kg/bag

Medroxyprogesterone 17-acetate 71-58-9 estrogen hormone raw material USP 1kg/bag

Medroxyprogesterone 17-acetate 71-58-9 estrogen hormone raw material USP 1kg/bag
Medroxyprogesterone 17-acetate 71-58-9 estrogen hormone raw material USP 1kg/bag

Large Image :  Medroxyprogesterone 17-acetate 71-58-9 estrogen hormone raw material USP 1kg/bag Get Best Price

Product Details:

Place of Origin: hubei
Brand Name: DKY
Model Number: 71-58-9

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg per year
Detailed Product Description
DeliveryTime: Prompt PackAge: 1kg Aluminum Foil Bag Or 25kg/drum
Storage: Store In Dry, Dark And Ventilated Place LimitNum: 500 Gram Or 1 Kilogram
Transportation: EMS、TNT、DHL、UPS、FEDEX Port: Any Port In China
Assay: 99% Shelf Life: Two Years
High Light:

female hormones estrogen

,

women hormones estrogen

Medroxyprogesterone 17-acetate 71-58-9 estrogen hormone raw material USP 1kg/bag
 
Basic parameter:
1. Product name :Medroxyprogesterone Acetate
2. Product nicknames :Medroxyprogesterone Acetate (Medroxyprogesterone 17-acetate); (6 - alpha) - 17 - (acetyloxy) - 6 - methylpreg - 4 - ene - 3, 20 - dione. 17 - (acetyloxy) - 6 - methyl - (6 - alpha) - pregn - 4 - ene - 20 - dione. 17 - (acetyloxy) - 6 - methyl - 20 - dion alpha (6) - pregn - 4 - ene -; 17 - acetoxy - 6 - alpha - methylprogesterone; 17 - alpha - hydroxy - 6 - alpha - methylpregn - 4 - ene - 3, 20 - dioneacetate; 17 - alpha - hydroxy - 6 - alpha - methyl - progesteronacetate; 17 - alpha - hydroxy - 6 - alpha - methylprogesteroneacetate
3. CAS no. : 71-58-9
4. Molecular formula: C24H34O4
5. Molecular weight: 386.52
6. EINECS no. : 200-757-9
7. Density: 1.13 g/cm3
8. Boiling point: 500.3°C at 760 mmHg
9. Flash: 215 ° C
10. Vapor pressure: 3.85E-10mmHg at 25°C
11. Melting point: 202 ~ 208℃
12. Refractive index: 48 ° (C=1, Dioxane)
13. Storage conditions: Refrigerator
14. Appearance: white or white-like crystalline powder; Odourless.
15. Solubility: soluble in trichloromethane, soluble in acetone, slightly soluble in ethyl acetate, slightly soluble in anhydrous ethanol, insoluble in water.
 
Certificate of Analysis:
Product name Medroxyprogesterone Acetate 71-58-9
Batch no 190206 Report date 00000-008
manufacturing date 2019/02/02 Retest date 2023/02/01
Packing 1kg/bag Quantity 2kg
Standard USP37
Inspection results
Inspection Item Standard Retest
Appearance White to whitish, odorless crystalline powder Conform
Identify A:IR,B:UV Conform
specific rotation +45~51° +50.55(C=1 Dioxane)

Any individual impurity

Total impurities

 

≤1.0%

≤1.5%

 

0.70%(HPLC)

0.89%(HPLC)

compound ≤0.5% Conform
Melting point About 205℃ 206.1~208.2℃
Dry weight loss ≤1.0% 0.13%
solubility Soluble in chloroform, acetone and dioxane, slightly soluble in ethanol and methanol, slightly soluble in ether, insoluble in water. Conform
The residual solvents
methanol
Methylene chloride

 

≤3000ppm

≤500ppm

Conform

Conform

content 97.0~103.0% 98.95%(HPLC)
fineness   100%≥40um
Conclusion Meet USP37.

 

structured:

Medroxyprogesterone 17-acetate 71-58-9 estrogen hormone raw material USP 1kg/bag 0

 

 

Pharmacological effects:
Progesterone is a powerful progesterone, which is effective by oral or injection. The progesterone activity is 20-30 times that of progesterone by subcutaneous injection, and 10-15 times that of progesterone by oral administration. This medicine also has the anti-estrogen effect, but does not antagonize the benign effect of estrogen on lipoprotein, also does not have the obvious androgen effect, is closest to the natural progesterone. The drug can increase the consistency of cervical mucus. It can also inhibit the release of luteinizing hormone (LH) from adenohypophysis through the negative feedback effect on hypothalamus, so that the follicle can not mature and inhibit ovarian ovulation, so it has contraceptive effect. When the blood concentration of the drug exceeds 0.1g/L, both LH and estradiol (E2) are inhibited, thereby preventing ovulation. The anti - tumor effect of angong progestin may be related to its anti - estrogen effect. In large doses, the drug can counteract the effect of estrogen on tumor cell growth, and has direct cytotoxic effect on sensitive cells, but not on drug-resistant cells. It can also reduce the level of estrogen in cells by enhancing the activity of e2-deoxyenzyme, induce liver 5 lebo-reductase, and prevent androgens from being converted into estrogen, thus producing anti-tumor effects. In addition, the drug can inhibit the production of LH ACTH and other growth factors through the negative feedback effect on adenohypophysis.
 
USES:
Progesterone is mainly used for dysmenorrhea, functional amenorrhea, functional uterine bleeding, threatened or habitual abortion, endometriosis, treatment of advanced breast cancer, endometrial adenocarcinoma and renal cancer. Large doses can be used as an intrauterine injection. Besides role in menstrual period for endometrial lost the support of the estrogen and progesterone after fall off, can continue to artificially supplement estrogen or progesterone progesterone, in particular, make "mutt" endometrial retain support, keep continue thickening, such growth of endometrial firmly in the uterine wall, ready for a fertilized egg implanted, attaining the aim of delayed menstruation.

 

 
 
 
 
 

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