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Mifepristone 84371-65-3 Estrogen Hormone Raw Material for Fight Early Pregnancy
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Detailed Product Description
| CAS No: | 84371-65-3 | Molecular Formula: | C29H35NO2 |
|---|---|---|---|
| Molecular Weight: | 429.59 | EINECS No: | 617-559-7 |
| Density: | 1.18g /cm3 | Melting Point: | 195-198 ° C |
| Boiling Point: | 628.6 C At 760 MmHg | Flash: | 334ºC |
| Refractive Index: | 1.623 | Stability: | Stable Under Normal Temperature And Pressure |
| Appearance: | Light Yellow Solid | Solubility: | Soluble In Methanol Or Dichloromethane, Dissolved In Ethanol Or Ethyl Acetate, Almost Insoluble In Water. |
| High Light: | female estrogen raw material,female hormones estrogen |
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Mifepristone 84371-65-3 estrogen hormone raw material used to fight early pregnancy
Basic parameter:
1. Product name :Mifepristone
2. Product alias: (8 s, r, s 13, 14 s, s) 17-11 - [4 - (dimethylamino) phenyl] - 17 - hydroxy - 13-17 - prop - methyl - 1 -,2,6,7,8,11,12,14,15,16 ynyl - 1 - decahydrocyclopenta [a] phenanthren - 3 - one; 11 - (4 - (dimethylamino) phenyl) - 17 - hydroxy - 17 - (1 - propynyl) - estra - 9 - dien - 3 - one; 11 beta - [4 - (n, n - dimethylamino) phenyl] - 17 alpha - (prop - 1 - ynyl) - delta4, 9 - estradiene; 17 - beta) - (11 - bet; 17 beta) - 11 - [4 - (dimethylamino) - phenyl] - 17 - hydroxy - 17 - (1 - propynyl estra) - (11 bet; 17 - beta - hydroxy - 11 - beta - (4 - dimethylaminophenyl - 1) - 17 - alpha - (prop - 1 - ynyl) oest; - 17 beta - ol - 3 - one; 4, 9 - dien - 3 - one
3. CAS no. : 84371-65-3
4. Molecular formula: C29H35NO2
5. Molecular weight: 429.59
6. EINECS no. : 617-559-7
7. Density: 1.18g /cm3
8. Melting point: 195-198 ° C
9. Boiling point: 628.6 C at 760 mmHg
10. Flash: 334 DHS C
11. Refractive index: 1.623
12. Stability: stable under normal temperature and pressure
13. Storage conditions: 2-8 C
14. Storage: 2-8°C, shading, sealed.
15. Appearance: light yellow solid
16. Solubility: soluble in methanol or dichloromethane, dissolved in ethanol or ethyl acetate, almost insoluble in water.
Production method:
Method 1:4, 9 female steroid diene - 3 - diketone 12 three ketal compounds (Ⅰ) as raw material, and propiolic magnesium bromide grignard reagent reaction, introduced in 17 propiolic base, compound (Ⅱ). Then the selective epoxidation of five olefinic bond, compounds (Ⅲ). Then in the copper - methyl bromide in sulfur ether complex tetrahydrofuran, and respond to dimethyl amino phenyl magnesium bromide, introduced in 11 of dimethyl amino phenyl, compounds (Ⅳ). Finally, mifepristone was hydrolyzed and dehydrated with hydrochloric acid in methanol. Yield of 21.5%.
Method 2: the 3 carbonyl groups were protected from 4,9 - estadiene -3, 17- diketone. Then it was epoxidation, followed by the introduction of a propargyl at the 17 position and a p-dimethylaminophenyl at the 11 position, and finally hydrolyzed to mifepristone. Compared with route 1, only the order of epoxidation and introduction of propargyl is different, and the reaction steps are the same. Total yield 35%-40%.
USES:
New anti-progesterone, with anti-glucocorticoid activity, but no progesterone, estrogen, androgen and anti-estrogen activity. The affinity with progesterone receptors is five times stronger than that with progesterone. It is used for preventing early pregnancy, inducing pregnancy and inducing intrauterine labor. It is used as a new anti-progesterone and has the activity of anti-glucocorticoid. Mifepristone has the function of resisting fertilized egg implantation, inducing menstruation and promoting cervical maturation. Its mechanism of inducing menstruation and stopping pregnancy is mainly to block the function of progesterone by competing with the progesterone receptor in the endometrium (decidual membrane). The affinity with progesterone receptors is five times stronger than that with progesterone. It is used for preventing early pregnancy, inducing pregnancy and inducing intrauterine labor.
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Contact Details
WuHan Dong Kang Yuan technology co., LTD
Contact Person: Angela
Tel: 86-15377658509
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