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Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss

Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss

Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss
Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss

Large Image :  Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss Get Best Price

Product Details:

Place of Origin: CHINA
Brand Name: DKY
Certification: ISO9001
Model Number: API

Payment & Shipping Terms:

Minimum Order Quantity: 1KG
Price: USD355/kg
Packaging Details: 25 kg cardboard drum
Delivery Time: 1work days
Payment Terms: T/T, Western Union, MoneyGram
Detailed Product Description
Name: Minoxidil Sulphate CAS: 83701-22-8
MF: C9H15N5O4S EINECS: 635-997-7
Content: 99% Whatapp: 153-2714-1851
High Light:

chemical hair loss treatment

,

anti hair loss treatment

Product Name: Minoxidil sulphate
Synonyms: Sulfuric acid minoxidil;Minoxidil sulfate (U-58838);minoxidilsulfateester;6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE-3-OXIDE SULFATE;MINOXIDIL SULFATE;MINOXIDIL SULPHATE;U-58838;MINOXIDIL SUFATE ETHYLATED
CAS: 83701-22-8
MF: C9H15N5O4S
MW: 289.31
EINECS: 635-997-7
 
Chemical Properties White Crystalline Solid
Uses A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14μM) vascular smooth muscle relaxant.
Uses specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite
Uses A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant
 
 

Physical and chemical properties

Appearance and properties: white crystalline powder

Density: 1.52 g/cm3

Melting point: 272-274°C (dec.)(lit.)

Boiling point: 351.7 C at 760 mmHg

Flash: DHS 166.5 C

Refractive index: 1.724

Stable at normal temperatures and pressures.

Storage: Keep in a cool, dry location. Keep containers closed when not in use. Protect from light.

 

 

The synthetic methods

4-chloro-2, 6-diaminopyrimidine was obtained by cyclization and chlorination of methyl cyanoacetate, then oxidized with perbenzoic acid to obtain 6-amino-1, 2-dihydro-1-hydroxy-2-imino4-chloropyrimidine (C4H5CIN4O), and finally obtained minolidine by condensation with hexahydropyridine

 

 

Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss 0Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss 1

 

 

Pharmacopoeia standard

Source (name), content (titer)

This product is 6- (1- piperidine) -2,4- pyrimidine diamine,3- oxide. C9H15N5O shall not be less than 99.0% as per dry product.

character

This product is white or white - like crystalline powder.

It is slightly soluble in ethanol, slightly soluble in chloroform or water, and extremely slightly soluble in acetone. Dissolved in glacial acetic acid.

To identify

(1) take this product, adding ethanol solvent and thinner each 1 ml contains about 6 mu g solution, according to the ultraviolet-visible spectrophotometry (2 2010 edition pharmacopoeia appendix Ⅳ A) determination, have the largest at the wavelength of 231 nm absorption.

(2) the infrared absorption spectrum of the product shall be consistent with the control spectrum (figure 608 of the infrared spectra collection of drugs).

check

Chlorinated compound

About 20 mg, take this product precision said, according to the oxygen flask combustion method (2 2010 edition pharmacopoeia appendix Ⅶ C) organic damage, with 10 ml of 0.1 mol/L sodium hydroxide solution as absorption liquid, after the course of burning, strong vibration wave for A few minutes, use A small amount of water to rinse the cork and platinum wire, lotion and people absorb liquid, remove the absorption liquid to 50 ml nessler tubes, according to the chloride method (2 2010 edition pharmacopoeia appendix Ⅷ A) inspection, and controlled liquid (with the test method of the operation, but does not contain in the filter paper test samples during burning, and join the standard sodium chloride solution of 4.0 ml), Not thicker (0.2%).

About the material

Take an appropriate amount of this product, accurately weigh it, dissolve it with mobile phase and dilute it to make a solution containing about 0.25mg per 1ml as the sample solution. An appropriate amount was precisely taken and diluted quantitatively with the mobile phase to make a solution containing about 2.5 g per 1ml as the control solution. According to high performance liquid chromatography (2 2010 edition pharmacopoeia appendix Ⅴ D) test. Using octadecylsilane bonded silica gel as filler; Methanol-water-glacial acetic acid (70:30:1) (containing 3.0g sodium dioctyl sulfonate per 1000ml, and adjusting the pH value to 3.0 with perchloric acid) was used as mobile phase. The detection wavelength is 240nm. The product and medroxyprogesterone acetate were dissolved in the mobile phase and diluted to make a mixture containing approximately 0.25mg each in 1ml. 10 solution l was taken and injected into the liquid chromatograph to record the chromatographic chart. The theoretical plate number was calculated according to minoxidil peak not less than 2000, and the separation degree of minoxidil peak and medroxyprogesterone acetate peak should be greater than 2.0. The control solution was precisely measured at 10 solution l and injected into the liquid chromatograph. The detection sensitivity was adjusted so that the peak height of the main component chromatographic peak was about 20% of the full range. The sample solution and the control solution were precisely measured at 10 solution l each and then injected into the liquid chromatograph. If there are impurity peaks in the chromatogram of the sample solution, the sum of the impurity peaks shall not be greater than the main peak area (1.0%) of the control solution.

Dry weight loss

Take this product, in 105 ℃ drying to constant weight, reduce weight loss may not be over 0.5% (2010 edition pharmacopoeia appendix Ⅷ L).

On ignition residue

Take this product is 1.0 g, in accordance with the inspection department ii (2010 edition pharmacopoeia appendix Ⅷ N), legacy residue may not be over 0.15%.

Heavy metal

Take on ignition residue of the residue left under, in accordance with the inspection (2 2010 edition pharmacopoeia appendix Ⅷ H second law), containing heavy metals shall not be twenty over one million.

Content determination

Take this product is about 0.15 g, precision said, add 50 ml glacial acetic acid, lukewarm dissolved, according to the potentiometric titration method (2 2010 edition pharmacopoeia appendix Ⅶ A), liquid with perchloric acid titration titration (0.1 mol/L), and the result of the titration correction by blank test. Each 1ml perchloric acid titrant (0.1mol/L) is equivalent to 20.93mg of C9H15N5O.

 

Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss 2

 

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Wuhan dongkangyuan technology co., LTD is located in jiangxia district, wuhan city, hubei province. Main pharmaceutical intermediates, bulk drugs, food additives, antibiotics bulk drugs. Wuhan dongkangyuan technology co., LTD., located in wuhan, a thoroughfare of nine provinces, is a high-tech company specializing in the r&d and sales of chemical raw materials in central China. The company has its own research and development base, equipped with advanced production equipment and efficient and precise testing instruments, with a complete, scientific, quality management system. And constantly committed to technological innovation, product innovation and management innovation, with high and new technology and excellent innovative quality service to win the trust of the majority of users in institutions of higher learning, scientific research units, pharmaceutical manufacturers, quality inspection departments, environmental protection enterprises, chemical production, agricultural production, food-related industries. To ensure that our products in the industry with strong competitiveness. The company has independent import and export rights and excellent sales team. With the diligent efforts of all employees, the company has opened a wide market. The company's products sell well all over the country and exported to Europe, America, southeast Asia and Africa and other countries and regions, win the majority of customers unanimously recognized and praise. "Honesty and service first; Kang yuan produces, must belong to high-quality goods ". Integrity management, customer satisfaction is our consistent purpose; The pursuit of quality, to provide customers with high quality products is our bounden duty. Welcome customers patronage. Get the general customer's approval. The company adheres to the business philosophy of "ensuring first-class quality and maintaining first-class reputation", and adheres to the principle of "customer first" to provide high-quality services for our customers. Welcome to call to discuss business!
Minoxidil Sulfate API 83701-22-8 White Crystalline Solid Against Hair Loss 3
 
Treated with androgen alopecia is therefore impossible to effectively, hormone class in the class because of alcohol hormones into cells and fixed on the extranuclear receptor, once together, they are transported to the cell nucleus, in the nucleus, they make DNA portion of special expression and controlled by RNA replication of reverse transcriptase, that the protein of the change of the cell metabolism. A stop hormone receptor cytoplasm or combine with DNA, the drug is characterized by exogenous the vitality of the male hormone, but with the special protein function and convey the hormone drugs should be selected by hormones and the joint role can produce a series of proteins, DNA minoxidil may be part of the characteristics of these proteins, if minoxidil occupy the site of these proteins, or combine with proteins, it will hinder the hormone induced to cell signal, this signal can make the hair stop, the result is as long as there is minoxidil, hair growth, There was no interference even in the treatment of other male hormones. I think what works best is that the proteins produced have the best chemical binding properties to minoxidil. It's less effective in people who have a lower affinity for minoxidil, and in those who don't have a response they have a different minoxidil reactant, and minoxidil helps us limit the expression of the bald gene.

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