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Pharma Raw Materials Isotretinoin 4759-48-2 Pharmaceutical API Intermediate

Pharma Raw Materials Isotretinoin 4759-48-2 Pharmaceutical API Intermediate

Pharma Raw Materials Isotretinoin 4759-48-2 Pharmaceutical API Intermediate
Pharma Raw Materials Isotretinoin 4759-48-2 Pharmaceutical API Intermediate

Large Image :  Pharma Raw Materials Isotretinoin 4759-48-2 Pharmaceutical API Intermediate Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: $8-12/g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 200 kgs per year
Detailed Product Description
DeliveryTime: Prompt PackAge: 1kg Aluminum Foil Bag Or 25kg/drum,according To The Clients Requirement
Storage: Store In Dry, Dark And Ventilated Place LimitNum: 500 Gram Or 1 Kilogram
Transportation: Air Or Ocean Or Rail Or Parcel Post(EMS、TNT、DHL、UPS、FEDEX),or According Your Requirement Port: Any Port In China
Shelf Life: Two Years Origin: Hubei
Transport Package: Discreet And Tight Specification: 100% Qualified
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CAS 4759-48-2 API Isotretinoin drugs Dongkangyuan Minimum Factory Price

 

Basic parameter:

1. Product Name: Isotretinoin
2. Synonyms: 13-cis-ra;13-cis-retinoicaci;13-ra;accutane;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
3. CAS: 4759-48-2
4. MF: C20H28O2
5. MW: 300.44
6. EINECS: 225-296-0
7. Isotretinoin Chemical Properties
8. Melting point 172-175 °C(lit.)
9. storage temp. −20°C
10. Water Solubility insoluble
 

Certificate of Analysis:                                

Product Name Isotretinoin Batch No. 20190723
MFG. Date 2019.07.23 Exp Date 2021.07.22
Quantity 50 g Accord to USP38
ITEMS SPECIFICATIONS RESULTS
Description Yellow or light orange,crystalline powder Complies
Identification

A:Infrared Absorption

B:Ultraviolet Absorption

Complies

Complies

Solubility Practically insoluble in water,soluble in methylene chloride,slightly soluble in alcohol Complies
Related Substances Tretinoin ≤1.0% 0.35%
Organic volatile impurity Complies Complies
Loss on drying ≤0.5% 0.1%
Residue on ignition ≤0.1% 0.03%
Residual Solvents

Methanol≤3000ppm

Ethyl Acetate≤5000ppm

Hexane≤290ppm

Complies

Complies

Complies

Heavy metals <0.002% <0.002%
Limit of Tretinoin ≤1.0% 0.15%
Assay 98.0%-102.0% 99.69%
Conclusion The product complies with USP38

 

Structure:

Pharma Raw Materials Isotretinoin 4759-48-2 Pharmaceutical API Intermediate 0

 

 

Pharmacological effects:
Isotretinoic acid belongs to the first generation of tretinoic acid, which is A stereoisomer of all-trans tretinoic acid. Oral administration has anti-grease effect and special effect on severe acne. The mechanism is as follows:
1. It can reduce the sebaceous glands, inhibit the activity of sebaceous glands and reduce the secretion of sebaceous glands, so as to inhibit the reproduction of propionibacterium acacia acne which depends on the growth of lipid environment.
2. It has the function of anti-keratinization, inhibiting the excessive proliferation of epidermal cells and promoting their differentiation, and can reduce the keratinization of hair follicle mouth and sebaceous gland duct.
3. It can also affect the function of monocytes and lymphocytes, inhibit the chemotaxis of neutrophils and have anti-inflammatory activity.
4. Selectively bind the tretinoic acid nuclear receptor to play A therapeutic role. Inhibition of the proliferation of probacteriaceae acne at low doses and immunosuppression at high doses.
5. Can inhibit the formation of collagenase and gelatinase in the skin, and can inhibit the activity of ornithine decarboxylase. Induction of ornithine decarboxylase can play A major role in skin mutation, so isotretinoic acid can also inhibit the occurrence of tumors.
6. When applied locally, the action mechanism of this product is similar to that of tretinoic acid, which can induce epidermal cell proliferation, promote epidermal cell granular layer to differentiate into cuticle layer, and regulate keratinocytes in the process of abnormal keratinization of hair follicle sebum epithelium, thus playing A therapeutic role.
 
Indications:
1. Isotretinoic acid is the first choice for refractory acne, especially for patients with severe nodular, cystic and inflammatory acne who have failed traditional treatment;
2. Generalized flat warts or verrucous epidermal dysplasia;
3. Abnormal keratotic dermatosis;
4. Cutaneous lupus erythematosus;
5. Lichen planus, sclerosing atrophic moss.

 

 

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