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pharmaceutical raw materials ketotifen fumarate 34580-14-8 API Manufacturer made in China

pharmaceutical raw materials ketotifen fumarate 34580-14-8 API Manufacturer made in China

pharmaceutical raw materials ketotifen fumarate 34580-14-8 API Manufacturer made in China
pharmaceutical raw materials ketotifen fumarate 34580-14-8 API Manufacturer made in China

Large Image :  pharmaceutical raw materials ketotifen fumarate 34580-14-8 API Manufacturer made in China Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: $8-12/g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 300 kgs per year
Detailed Product Description
CAS No: 34580-14-8 Molecular Formula: C23H23NO5S
Molecular Weight: 425.5 EINECS No: 252-100-0
Melting Point: - 43 ° C Density: 0.968g/mLat 25°C
Flash: 96-98 ° C Boiling Point: 250-263 ° C
Storage Conditions: Store At RT Solubility: Sparingly Soluble In Water, Slightly Soluble In Methanol, Very Slightly Soluble In Acetonitrile.
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pharmaceutical raw materials ketotifen fumarate 34580-14-8 API Manufacturer made in China
 
Basic parameter:
1. Product name :Ketotifenfumarate
2. Product alias :zaditen; KetotifenHydrogenFuMarate, EP; 4, 9 - Dihydro - 4 - (1 - Methyl - 4 - piperidinylidene) - 10 h - benzo [4, 5) cyclohepta [1, 2 - b] thiophen - 10 - one (e) 2-2 - Butenedioate; Totifen; Zasten; KetotifenFuMarateAPI; 4 - (1-4 - ylidene Methylpiperidin -) - 4 h - benzo [4, 5) cyclohepta [1, 2 - b] thiophen - 10 9 (h) - onefuMarate; ketotifenfuMarat
3. CAS no. : 34580-14-8
4. Molecular formula: C23H23NO5S
5. Molecular weight: 425.5
6. EINECS no. : 252-100-0
7. Melting point: 192 ℃
8. Density: 0.968g/mLat 25°C(lit.)
9. Flash: 96-98 ° C / 5 mm
10. Melting point: - 43 ° C
11. Boiling point: 250-263 ° C (lit.)
12. Storage conditions: Store at RT
13. Solubility: Sparingly soluble in water, slightly soluble in methanol, very slightly soluble in acetonitrile.

 

Certificate of Analysis:

PRODUCT NAME KETOTIFEN FUMARATE
Batch No.: 20191102 Date of Manufature 2019.11.02
Batch Size 30kg Certificate Date 2019.11.02
Specification EP Ⅳ Date of Expiry 2021.11
Test Specification Results
Appearance White to brownish-yellow,fine,crystalline powder Complies
Solubility Sparingly soluble in water , slightly soluble in Methanol , very slightly soluble in acetonifrile Complies
Identification TLC Complies
IR spectrum Complies
Clarity and colour of solution Clear and not more than Y4BY4B4 <BY4
Loss on drying Not more than 0.5% 0.20%
Sulphated ash Not more than 0.1% 0.02%

Related substances(HPLC)

Impurity A

Impurity G

Single unknown impurity

Total impurities

 

Not more than 0.2%

Not more than 0.2%

Not more than 0. 15%

Not more than 0.5%

 

N.D

0.07%

N.D

0.07%

Residual solvents

Acetone≤5000ppm

Methanol≤500ppm

1750ppm

<1ppm

Assay(potetiometic titration)

Calculated on the dried basis

Between 98.5% and 101.0% 99.55%
Conclusion Complies  

 

Structure:

pharmaceutical raw materials ketotifen fumarate 34580-14-8 API Manufacturer made in China 0

 

 

Indications:
Dermatology is used for allergic diseases such as urticaria, pruritus, eczema, allergic dermatitis, atopic dermatitis, neurodermatitis, etc. It has recently been reported that the treatment of scleroderma is effective. Internal medicine has a very good effect on bronchial asthma, and a significant effect on allergic asthma, followed by the mixed type, about half of the infected type, which has a preventive effect on asthma.
 
Pharmacological effects:
The pharmacological effects of ketotifen fumarate are relatively complex, and it has achieved certain effects in the prevention and treatment of asthma and childhood asthma, but the detailed mechanism of its pharmacology is still unclear. From the point of the present research situation, ketone of fumaric acid for Finn pharmacological mechanism of prevention and treatment of asthma and asthma in children mainly includes the following aspects: 1. The antagonism of inflammatory medium: clinical studies have confirmed ketone of fumaric acid for Finn can effectively inhibit histamine induced bronchospasm, its strength and Azelastine are similar, the prompt ketone of fumaric acid for Finn has strong histamine antagonist effect. Modern studies have shown that ketotifen fumarate can also antagonize inflammatory mediators such as leukotrienes and platelet activators, so ketotifen can be considered as a drug that can antagonize a variety of inflammatory mediators, which may be one of the main mechanisms for the prevention and treatment of asthma and childhood asthma. 2. Mast cell/eosinophil cell membrane protective effect: pharmacological studies of ketotifen fumarate have confirmed that it can inhibit the release of histamine, leukotriene and platelet activator by mast cell/eosinophil granulocytes, suggesting that it has a strong mast cell/eosinophil cell membrane protective effect. This may be the main mechanism for ketotifen fumarate to prevent and treat asthma and childhood asthma. 3. Inhibition of airway inflammatory cell infiltration: ketotifen fumarate can inhibit the airway infiltration of eosinophils and neutrophils, the mechanism of which is still unclear. 4. Regulation of T cell activity: ketotifen fumarate inhibits IgE synthesis in vivo by regulating the release activity of CD4+ and CD8+ lymphocytes. The mechanism by which ketotifen fumarate inhibits IgE synthesis and the two mechanisms above determine the airway anti-inflammatory effect of ketotifen fumarate. 5. Other effects: some studies have shown that ketotifene fumarate can reverse the hyporegulation of LRT induced by LRT and increase LRT density in the airway, and can enhance the role of LRT agonists. Some studies have also shown that ketotifen fumarate has a calcium channel blocking effect.

 

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