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Ropivacaine HCl 132112-35-7 Pharma Raw Materials Used For Anesthesia
Product Details:
Payment & Shipping Terms:
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Detailed Product Description
| CAS No: | 132112-35-7 | Molecular Formula: | C17H26N2O. ClH. H2O |
|---|---|---|---|
| Molecular Weight: | 328.88 | EINECS No: | 663-286-1 |
| Melting Point: | 267-269 ° C | Flash: | 218.8 ° C |
| Vapor Pressure: | 4.37E-08mmHg At 25°C | Specific Rotation: | D20-7.28 ° (c = 2 In Water) |
| Solubility: H2O: | Soluble5mg/mL, Clear | Boiling Point: | 495.9°C At 760 MmHg |
| Optical Activity: | [α]/D -9 To -12, C = 1 In Methanol | Appearance: | White To Almost White Crystal Or Crystalline Powder |
| High Light: | caine medicine raw material,caine raw material powder |
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Ropivacaine HCl 132112-35-7 Caine Series Pharma Raw Materials used for anesthesia
Basic parameter:
1. Product name: Ropivacainehydrochloride
2. Alias: (S) - 1 - propyl - 2 ', 6 '- dimethylanilinoformoxylpiperidinemonohydrochloridemonohydrate; (S) - 1 - propyl - 2 ', 6 '- dimethylanilinoformoxylpiperidine, monohydrochloride, monohydrate; (S) - Ropivaxainehydrochloride; (S) - N - (2, 6 - dimethylphenyl) - 1 - propylpiperidine - 2 - carboxamidehydrochloride; Ropivacainehydrochloride; (2 s) - N - (2, 6 - Dimethylphenyl) - 1 - propyl - 2 - piperidinecarboxamideHydrochlorideHydrate; LEA - 103; (S) - ropivacainehydrochloridehydrate
3. CAS no. : 132112-35-7
4. Molecular formula: C17H26N2O. ClH. H2O
5. Molecular weight: 328.88
6. EINECS no. : 663-286-1
7. Melting point: 267-269 ° C
8. Flash: 218.8 ° C
9. Vapor pressure: 4.37E-08mmHg at 25°C
10. Specific rotation: d20-7.28 ° (c = 2 in water)
11. Storage conditions: Refrigerator
12. Solubility: H2O: soluble5mg/mL, clear
13. Boiling point: 495.9°C at 760 mmHg
14. Optical activity: [PI]/ d-9 to -12, c = 1 in methanol
15. Appearance: white to almost white crystal or crystalline powder
Certificate of Analysis:
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Product name |
Ropivacaine HCL |
Quantity |
25KG |
|
batch No. |
190920 |
Mfg. date |
2019.09.20 |
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Test Date |
2019.09.28 |
Retest date |
2021.09.19 |
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Tests |
Results |
Specifications |
|
Description |
Complies |
White, crystalline powder |
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Solubility |
Complies |
Soluble in water |
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Identification |
Complies |
A: By IR, To match with working standard |
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Complies |
B: Test for chlorides. Reponds to the test for Chlorides. |
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Color |
0.007 |
NMT 0.030 at 405nm, and m. |
|
0.001 |
NMT 0.025 at 436nm |
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Clarity |
Complies |
Meets the requirements |
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pH |
5.18 |
4.5~6.0 |
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Water |
5.56% |
5.0%~6.0% |
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Heavy metal |
﹤0.001% |
≤ 0.001% |
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Organic impurity |
Bupivacaine |
N.D. |
≤ 0.2% |
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Any other individual impurity |
0.0061% |
≤ 0.1% |
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Total impurities |
0.018% |
≤ 0.5% |
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Ropivacaine Related compound A |
Not detect |
≤ 10ppm |
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Enantiomeric purity |
Not detect |
≤ 0.5% |
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Residual Solvents |
Not detect |
Ethyl alcohol ≤ 0.5% |
|
0.09% |
Acetone≤ 0.5% |
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|
Not detect |
4-methyl-2-pentone ≤ 0.5% |
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Assay |
99.32% |
98.5~101.0% |
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Conclusion : Conforms to USP41 |
Structure:
Pharmacological effects:
Since the discovery that long-acting local anesthetics can induce cardiac arrest, people have been looking for safer and less fat-soluble alternatives. Ropivacaine is such a new type of long-acting amide local anesthetic, its action lasts a long time, and has anesthetic and analgesic effects. Its pharmacologic features are low cardiotoxicity, obvious separation of sensory block from motor block, and peripheral constriction. Therefore, the drug is especially suitable for postoperative analgesia and obstetric anesthesia.
Compared with traditional local anesthetics, ropivacaine has the following advantages:
1. Curative effect -- the effect time of ropivacaine was significantly longer than that of other long-acting local anesthetics, and the effect time of subcutaneous infiltration was 2 to 3 times longer than that of bupivacaine of the same concentration.
2. Unique curative effect -- the separation degree of sensory and motor block of ropivacaine is much higher than that of bupivacaine, and the clearance rate is higher, making it more suitable for analgesia.
3. High controllability -- the anesthetic effect of ropivacaine is dose-dependent, that is to say, the degree of sensory and motor retardation produced by ropivacaine is predictable and controllable.
4. Low toxic and side effects -- ropivacaine does not have the disadvantage of greater cardiac toxicity of general long-acting local anesthetics. Cardiac toxicity rarely occurs in this product, and the fetus has good tolerance to this product.
Contact Details
WuHan Dong Kang Yuan technology co., LTD
Contact Person: Angela
Tel: 86-15377658509
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