WuHan Dong Kang Yuan Technology co., LTD

 

Integrity-based service-oriented Kangyuan products must be boutiques.

Home
Products
About Us
Factory Tour
Quality Control
Contact Us
Request A Quote
Home ProductsPharmaceutical Intermediates

tacrolimus 109581-93-3 pharmaceutical raw material for scientific research

tacrolimus 109581-93-3 pharmaceutical raw material for scientific research

tacrolimus 109581-93-3 pharmaceutical raw material for scientific research
tacrolimus 109581-93-3 pharmaceutical raw material for scientific research

Large Image :  tacrolimus 109581-93-3 pharmaceutical raw material for scientific research Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: 109581-93-3

Payment & Shipping Terms:

Minimum Order Quantity: 1g
Packaging Details: 1g/bag
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 10kg per year
Detailed Product Description
CAS No: 109581-93-3 Molecular Formula: C44H71NO13
Molecular Weight: 822.0335 Melting Point: 127-129 °
Boiling Point: 871.7 °C At 760 MmHg Flash Point: 481 °C
Specific Rotation: D23 -84.4° (c = 1.02 In Chloroform) Storage Conditions: -20°C
Solubility: DMSO: Soluble20mg/mL Appearence: White Crystalline Powder
High Light:

pharma raw material

,

raw pharmaceutical materials

tacrolimus 109581-93-3 pharmaceutical raw material for scientific research
 
Basic parameter:
1. Product name :tacrolimus
2. Product alias: fk-506; Tacarolimus; Tacrolimushydrate; Fk1 - FK - 506 monohydrate; Tacrolimus (150 mg); Tsukubaenolidehydrate; Tacrolimusmonohydrate; Tacrolimusmonohydroate; Fk1 - FK - 506 monohydrate, > = 98%. Tacrolimus/FK506monohydrate
3. CAS: 109581-93-3
4. Molecular formula: C44H71NO13
5. Molecular weight: 822.0335
6. Melting point: 127-129 °
7. Boiling point: 871.7 °C at 760 mmHg
8. Flash point: 481 °C
9. Specific rotation: d23-84.4 ° (c = 1.02 in chloroform)
10. Storage conditions: -20°C
11. Solubility :DMSO: soluble20mg/mL
 
Certificate of Analysis:

Product Name:Tacrolimus

Quantity:100 g

Batch No.:20191123

Producing date: 2019.11.23

Analysis date:2019.11.23

Expiry date:2年

Reference standard:enterprise standard

Items

Specifications

Results

Appearance

White crystalline powder

White crystalline powder

Identification

Positive Positive

Assay %

≥95.0% 98.5%

Loss of drying %

≤3.0% 2.2%

Residue on ignition %

≤0.1% 0.08%

Heavy metals (as Pb),ppm

0.001% max <0.001%

Related compounds

(1)FK-506II

(2)FK-520

(3)II(IsomerII)

 

2.1%

0.0%

2.4%

 (sum of all impurity) 3.0% max 2.5%

Conclusion:This product conforms enterprise standard

 

Structure:

tacrolimus 109581-93-3 pharmaceutical raw material for scientific research 0

 
Pharmacological effects:
At the molecular level, tacrolimus apparently works by binding to a cellular protein (FKBP12) and accumulating in the cell to produce its effect. The FKBP12- tarkerus complex binds specifically and inhibits calcinurin, which inhibits the calcium ion-dependent signaling pathway produced in T cells, thereby preventing the transcription of discontinuous lymphocyte factor genes. This drug is a highly immunosuppressive drug and its activity has been confirmed in vitro and in vivo experiments. This drug inhibits the formation of cytotoxic lymphocytes that are the primary mechanism of graft rejection. This drug inhibits the activation of T cells and the proliferation of T helper cells dependent on B cells. It also inhibited the production of lymphocyte factors such as interleukin-2, interleukin-3, and shap-interferon, as well as the expression of interleukin-2 receptors. At the molecular level, the drug's effects appear to be caused by binding to a cellular protein (FKBP) that also causes the compound to accumulate between cells. The drug has been shown to be effective for liver and kidney transplantation in vivo.
 
I am Angela
Contact Angela, you would never regret.
email: zs@dkybpc.com
Tel: +86-15377658509, you can add me on WeChat or Skype or Whatsapp if you are using that.

Contact Details
WuHan Dong Kang Yuan technology co., LTD

Contact Person: Angela

Tel: 86-15377658509

Send your inquiry directly to us