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|Standard:||USP||Packaging:||25 Kg Cardboard Drum|
pharmaceutical formulation intermediates
|Benzimidazole Chemical Properties|
|Melting point||169-171 °C(lit.)|
|Boiling point||360 °C|
|density||1.1151 (rough estimate)|
|refractive index||1.5500 (estimate)|
|storage temp.||Store below +30°C.|
It is obtained by cyclization of o-phenylenediamine and formic acid. The mixture of o-phenylenediamine and formic acid was heated in a water bath for 2h and cooled. The pH was adjusted to 10 with 10% sodium hydroxide solution. The crude product was slightly boiled with water, decolorized with activated carbon, filtered while hot, and the filtrate was cooled to room temperature, filtered and washed in cold water. The finished product was dried at 100℃. Crude product yield 90%.
The preparation method is to add the crushed o-phenylenediamine into the reaction kettle, then pump the formic acid, keep the reaction temperature at 95 ~ 98℃ and stir for 2h, cool down and crystallize, then neutralize with 10% NaOH to slightly alkaline, cool down and filter, wash with water and dry to get benzimidazole.
Benzimidazole is a chemical whose molecular formula is C7H6N2. Benzimidazole is a flake crystal, m.p.170℃, soluble in water and ethanol. Benzimidazole can be used to prepare fungicide imidazole and imidazole.
Wuhan dongkangyuan technology co., ltd. was founded on April 26, 2002, formerly known as wuhan dongkangyuan chemical pharmaceutical co., LTD. On April 26, 2013, wuhan dongkangyuan technology co., LTD. Was established as a whole. Wuhan dongkangyuan science and technology co., LTD. Is one of the comprehensive manufacturing enterprises of antifungic-based API, which has established bio-chemical industry and plant extract, and is an important production and export base of pharmaceutical products in central China.
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