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Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry

Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry

Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry
Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry

Large Image :  Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry Get Best Price

Product Details:

Place of Origin: CHINA
Brand Name: DKY
Certification: GB,ISO9001
Model Number: USP

Payment & Shipping Terms:

Minimum Order Quantity: 25kg
Price: USD500/25kg
Packaging Details: 25kg kraft paper bags
Delivery Time: 1DAY
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000T
Detailed Product Description
Appearance: White Powder Purity: 99%
Cas No.: 9004-32-4 Einecs No.: 618-378-6
Use: Pharmaceutical Accessories, Food Additives, Industrial Applications Packing Specification: 25kg Kraft Paper Bags
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raw materials for drugs


pharmaceutical industry raw materials

Carboxymethylcellulose Sodium Powder Is Used Widely In The Pharmaceutical Excipients Industry
Product Name: Carboxymethyl cellulose
Synonyms: CARBOXYMETHYL CELLULOSE, SODIUM SALT, AV ERAGE MW CA. 250,000, DS = 0.7;CARBOXYMETHYL CELLULOSE, SODIUM SALT, AV ERAGE MW CA. 90,000, DS = 0.7;VistecD.1.;VistecD.1.SGrade;CarboxymethylCelluloseSodiumSalt(MedViscosity500-600Cps;CarboxymethylCelluloseSodiumSaltHighViscosity500-600Cps;VistecC.1.SGrade;CrossCarmiloseSodium
CAS: 9004-32-4
EINECS: 618-378-6
Product Features Carboxymethyl cellulose (CMC) is tackifier, at room temperature, it is non-toxic tasteless white flocculent powder, it is stable and soluble in water, aqueous solution is neutral or alkaline transparent viscous liquid, it is soluble in other water-soluble gums and resins, it is insoluble in organic solvents such as ethanol. Carboxymethyl cellulose is the substituted product of cellulosic carboxymethyl group. According to their molecular weight or degree of substitution, it can be completely dissolved or insoluble polymer, the latter can be used as the weak acid cation of exchanger to separate neutral or basic proteins.
Carboxymethyl cellulose can form highly viscous colloidal solution with adhesive, thickening, flowing, emulsifying, shaping, water, protective colloid, film forming, acid, salt, suspensions and other characteristics, and it is physiologically harmless, so it is widely used in the food,
Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry 0
pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.
Uses It is used in cigarette adhesive, fabric sizing, footwear paste meal, home slimy. It is used in interior painting architectural, building lines melamine, thickening mortar, concrete enhancement. It is used in refractory fiber, ceramic production molding bond. It is used in oil drilling, exploration address slurry thickening, reducing water loss, quality paper surface sizing. It can be used as soap and washing powder detergent active additives, as well as other industrial production on the dispersion, emulsification, stability, suspension, film, paper, polishing and the like. Quality product can be used for toothpaste, medicine, food and other industrial sectors.
CMC can significantly increase the viscosity of the solution as thickener, dispersion, emulsification, suspension, protective colloid and so on when it is dissolved in water, and it is physiologically harmless, it is widely used in the food, pharmaceutical, cosmetic, oil, paper, textiles, construction and other areas of production.
Usage Instruction Use warm water or cold water when preparing the solution, and stir till it completely melts. The amout of added water depends on variety and the use of multiple requirements.
High viscosity sodium carboxymethyl cellulose (HV-CMC) is a white or slightly yellow fibrous powder, hygroscopic, odorless, tasteless, non-toxic, easy to ferment, insoluble in acids, alcohols and organic solvents, easily dispersed to form colloidal solution in water. It is reacted by the acid and fibrous cotton, it is mainly used for water-based drilling fluids tackifier, it has certain role of fluid loss, it has strong salt and temperature resistance especially.

The main application

Widely used in oil industry drilling mud treatment agent, synthetic detergent, organic washing aid, textile printing and dyeing sizing agent, daily chemical products water-soluble adhesive viscosifier, pharmaceutical industry viscosifier and emulsifier, food industry thickener, ceramic industry adhesive, industrial paste, paper industry sizing agent. It is used as flocculant in water treatment, mainly in wastewater and sludge treatment, which can improve the solid content of filter cake.

Sodium carboxymethyl cellulose is also a thickener, because of its own good functional characteristics make it has been widely used in the food industry, it has also promoted the rapid and healthy development of the food industry to a certain extent. If it has a certain thickening emulsification, it can be used to stabilize sour milk drinks and increase the viscosity of yogurt system; Because of its hydrophilic and complex water, it can be used to improve the food quality of bread, steamed bread and other pasta products, extend the shelf life of pasta products, improve the taste; Because it has a certain gel effect, is conducive to the formation of food better gel, so it can be used in the manufacture of jelly and jam; It can also be used as edible coating material, mixed with other thickening agent, daubed on the surface of some food, can maximize food preservation, and because it is edible material, will not cause adverse effects on human health. Therefore, cmc-na of edible grade, as an ideal food additive, is widely used in food production in food industry.


Sodium carboxymethyl cellulose crosslinked

Cross-linked carboxymethyl cellulose sodium (Croscamellose sodium) is a kind of sodium carboxymethyl cellulose in certain conditions for cross-linking reaction and become an insoluble in water and swelling to the original volume of 4~8 times the cross-linked polymer, commonly used as tablets, capsules disintegration agent.

Some scholars have developed a thickening agent suitable for the characteristics of tomato paste by cross-linking carboxymethyl cellulose technology, and established a cross-linking reaction test of carboxymethyl cellulose with propylene oxide as the cross-linking agent. The results showed that the cmc-na was suitable for the thickening of tomato paste.



Preparation of sodium carboxymethyl cellulose

Cmc-na was prepared from cellulose by a two-step method. First is the process of cellulose alkalization. Cellulose reacts with sodium hydroxide to produce alkali cellulose, and then alkali cellulose reacts with chloroacetic acid to produce cmc-na, which is called etherification.

The reaction system must be basic. The process belongs to Williamson ether synthesis. The reaction mechanism is nucleophilic substitution. The reaction system is alkaline, which is accompanied by some side reactions in the presence of water, such as the generation of by-products such as sodium hydroxylacetate and hydroxylacetic acid. Due to the existence of side reactions, the consumption of alkali and etherifying agent will be increased, thus reducing the etherifying efficiency. At the same time, sodium oxyacetic acid, oxyacetic acid and more salt impurities will be generated in the side reaction, resulting in reduced purity and performance of the product. In order to suppress side reactions, rational use of alkali, control of water system dosage, concentration of alkali and stirring mode should be taken into account for the purpose of full alkalinization. At the same time, requirements for viscosity and substitution degree of products should also be taken into account. Factors such as stirring speed and temperature control should be taken into comprehensive consideration to increase etherification rate and inhibit side reactions.

According to the different etherified media, the industrial production of cmi-na can be divided into two categories: water-medium method and solvent method. The method using water as the reaction medium is called the water-medium method and is used to produce cmc-na at medium and low alkaline levels. The method using organic solvent as reaction medium, called solvent method, is suitable for the production of medium and high grade cmc-na. These two reactions are carried out in kneading machines, which belong to kneading process and are the main methods of cmc-na production at present.

Water medium method

Water-based process is an early industrial process in which alkali cellulose and etherifying agent react under the conditions of free alkali and water. In the process of alkalization and etherification, there is no organic medium in the system. The equipment of water - borne method is simple, low investment and low cost. The disadvantage is the lack of a large number of liquid medium, the heat generated by the reaction makes the temperature rise, speeding up the speed of side reactions, resulting in low etherification efficiency, poor product quality and so on. This method is used to prepare medium and low grade cmc-na products, such as detergent and textile sizing agent.


Carboxymethylcellulose Sodium Powder for Pharmaceutical Excipients Industry 1

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