CAS19387-91-8 API Tinidazole Raw Materials Used In Pharmaceutical Industry

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CAS19387-91-8 API Tinidazole Raw Materials Used In Pharmaceutical Industry

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Product Details:

Place of Origin:	China
Brand Name:	DKY

Payment & Shipping Terms:

Minimum Order Quantity:	1kg
Price:	$80-100/kg
Packaging Details:	1kg/bag or 25kg/drum
Delivery Time:	5-7 work days
Payment Terms:	T/T, Western Union, MoneyGram
Supply Ability:	200 tons per year

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Detailed Product Description

DeliveryTime:	Prompt	PackAge:	1kg Aluminum Foil Bag Or 25kg/drum，according To The Clients Requirement
Storage:	Store In Dry, Dark And Ventilated Place	LimitNum:	500 Gram Or 1 Kilogram
Transportation:	Air Or Ocean Or Rail Or Parcel Post（EMS、TNT、DHL、UPS、FEDEX），or According Your Requirement	Port:	Any Port In China
Assay:	99%	Shelf Life:	Two Years
Transport Package:	Discreet And Tight	Specification:	100% Qualified
High Light:	pharma raw material , raw pharmaceutical materials

99%CAS19387-91-8 Drugs API Tinidazole pharmaceutical raw materials

Basic parameter:
1. Product Name: Tinidazole
2. Synonyms: TIMTEC-BB SBB006917;TINIDAZOLE;1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-1h-imidazol;1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro-imidazol;1-(2-(ethylsulfonyl)-ethyl)-2-methyl-5-nitroimidazole;bioshik;cp12574;ethyl(2-(2-methyl-5-nitro-1-imidazolyl)ethyl)sulfone
3. CAS: 19387-91-8
4. MF: C8H13N3O4S
5. MW: 247.27
6. EINECS: 243-014-4
7. Tinidazole Usage And Synthesis
8. Chemical Properties solid
9. Usage Antiprotozoal (Trichomonas, Giardia); antiamebic; antibacterial.
10. Usage anticonvulsant
11. Usage anti-ulcerative
12. Usage For the treatment of trichomoniasis caused by T. vaginalis in both female and male patients. Also for the treatment of giardiasis caused by G. duodenalis in both adults and pediatric patients older than three years of age and for the treatment of intestin

Certificate of Analysis:

Product name	Tinidazole	Batch no.	20191101
Quantity	25kg	Packaging	25 kg/barrel
Manufacturing date	2019.11.01	Report date	2019.11.12
Shelf life	2021.10.31	Inspection basis	CP2010

Project	Standard	Result
Appearance	Should be white to light yellow crystalline or crystalline powder, slightly bitter taste.	It is a light yellow crystalline powder with a slightly bitter taste.
Solubility	Meet the regulations	Conform
Melting point	125~129℃	125~127℃
Absorption coefficient	352-378	371
Identify	Should be positive.	positive
	Should be positive.	positive
	The infrared absorption spectrum of this product should be consistent with the control spectrum (spectrum set figure 665).	The infrared absorption spectra of this product should be consistent with those of the control.
Color of the solution	Should be positive.	positive
Related substance	≤1.0%	positive
Xylene	2170 ppm	positive
Loss on drying	≤0.5%	0.07%
Residue on ignition	≤0.1%	0.05%
Heavy metal	≤10ppm	10ppm
Microbial limit test	Number of bacteria: ≤300 /g	positive
	Mold and yeast: ≤60 / g	positive
	E. coli: not to be detected	positive
Assay	≤99.0%	99.9%

Conclusion

The product was tested according to the second part of the 2010 edition of Chinese pharmacopoeia and the enterprise internal control standards, and the results were in accordance with the provisions.

Structure:

Pharmacological effects:
Tinidazole and metronidazole belong to nitroimidazoles. It has good activity to protozoa (amoeba lysate, trichomonas vaginalis, etc.) and anaerobe. The effect on amoeba and giardia ransii was superior to metronidazole. Gram-positive anaerobe (gastrococcus, streptococcus, lactobacillus), clostridium difficile and clostridium difficile were all sensitive to this product. This product is slightly more effective than metronidazole on gram-negative anaerobes such as fragile bacilli, fusobacteria and fischeri, while campylobacter jejuni is moderately sensitive to this product. Actinomycetes and propionibacterium were resistant to the drug. Its mechanism of action is to inhibit the pathogen DNA synthesis, and can quickly enter the cell.

Indications:
This product is often used in combination with other anti-aerobic drugs for the treatment of sepsis, respiratory tract infection, abdominal and pelvic infection, unclean abortion and cellulitis caused by various anaerobic bacteria [4]. Satisfactory results can be obtained. The product can also be used in combination with aminoglycosides and other antibiotics to prevent postoperative infection in surgical colon, rectal surgery, oral surgery and obstetrics and gynecology. The recovery rate of tinidazole in the treatment of trichomoniasis, giardia lamblia and amoebiasis was more than 90%. For the treatment of male and female urogenital trichomoniasis; Infections caused by sensitive anaerobe (such as bacteroides fragilis, other bacteroides, gastroenterococcus, clostridium difficile, clostridium difficile, etc.), such as pneumonia, pulmonary abscess and other respiratory tract infections, intraperitoneal infection, endometritis, tubal abscess and other gynecological infections, periodontitis, pericoronitis and other oral infections. Systemic and local infections for anaerobic bacteria, such as abdominal, gynecological, surgical wounds, skin and soft tissue, lung, thoracic and other site infections, as well as septicaemia, intestinal or urogenital trichomoniasis, piriform giardia, and intestinal and hepatic amoebiasis.

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