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Dexamethasone Acetate 1177-87-3 skin care raw materials for rheumatoid arthritis
Product Details:
Payment & Shipping Terms:
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Detailed Product Description
| CAS No: | 1177-87-3 | Molecular Formula: | C24H31FO6 |
|---|---|---|---|
| Molecular Weight: | 434.5 | EINECS No: | 214-646-8 |
| Melting Point: | 238-240 ° C | Specific Rotation: | D25+73°(chloroform); D + 77.6 ° (Oliveto) |
| Boiling Point: | 579.4±50.0°C | Density: | 1.1517 |
| Refractive Index: | 87°(C=1,Dioxane) | Storage Conditions: | 2-8°C |
| Appearance: | White Or Almost White Crystalline Powder, Odorless, Slightly Bitter. | Solubility: | Soluble In Acetone, In Methanol Or Ethanol, Slightly Soluble In Ethanol Or Chloroform, Very Slightly Dissolved In Ether, Insoluble In Water. |
| High Light: | skin api,skin treatment chemicals |
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Dexamethasone Acetate 1177-87-3 skin care raw materials for rheumatoid arthritis
Basic parameter:
1. Product name: dexamethasone-17-acetate
2. Product alias: 4 - (9 - fluoro - 11 - dihydroxy - 10,13,16 - trimethyl - 4 - oxo - 6,7,8,11,12,14,15,16 - octahydrocyclopenta [a] phenanthren - 17 - yl) - 3 - hydroxy - 4 - oxobutanoate; 20 - dione, 9 - fluoro - 11 - beta, 17, 21 - trihydroxy - 16 - alpha - methyl - 4 - diene pregna - - 3; 9 the alpha - Fluoro - 16 alpha - methylprednisoloneacetate; ,17,21 - trihydroxy 9 - Fluoro - 11-16 - methylpregna - 1, 4 - diene - 3, 20 - dione21 - acetate; 9 - Fluoro - 11 - dihydroxy - 16 - methyl - 4 - dioxopregna - 1, 4-11 dien - 21 - ylacetate; 9 - fluoro - 11 - beta, 17, 21 - trihydroxy - 16 - alpha - methylpregna - 1, 4 - diene - 3, 20 - dione. 9 - Fluoro - 11 beta, 17, 21 - trihydroxy - 16 alpha - methylpregna - 1, 4 - diene - 3, 20 - dione21 - acetate; 9 - Fluoro - 11 - beta, 17, 21 - trihydroxy - 16 - alpha - methylpregna - 1, 4 - diene - 3, 20 - dioneacetate
3. CAS no. : 1177-87-3
4. Molecular formula: C24H31FO6
5. Molecular weight: 434.5
6. EINECS no. : 214-646-8
7. Melting point: 238-240 ° C (lit.)
8. Specific rotation :D25+73°(chloroform)(Arth,1958); D + 77.6 ° (Oliveto)
9. Boiling point: 579.4 + / - 50.0 ° C
10. Density: 1.1517
11. refractive index: 87 ° (C = 1, Dioxane)
12. Storage conditions :2-8°C
13. Solubility: Soluble at 100 mg/ml in acetone
14. Appearance: white or almost white crystalline powder, odorless, slightly bitter.
15. Solubility: soluble in acetone, in methanol or ethanol, slightly soluble in ethanol or chloroform, very slightly dissolved in ether, insoluble in water.
Certificate of Analysis:
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Product Name |
Dexamethasone Acetate |
Source |
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Batch Number |
20190707 |
Manufacture Date |
2019.07.07 | ||
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Quantity |
8kg |
Expiry Date |
2022.07.06 | ||
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Standards |
EUROPEAN PHARMACOPOEIA 6.0 |
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| Test Items | Specifications | Results | |||
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Appearance |
White or almost white, crystalline powder |
Conform |
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Solubility |
insoluble in water, freely soluble in acetone and in ethanol (96 per cent), slightly soluble in methylene chloride |
Conform |
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Specific Optical Rotation |
+84º~ +90º | +88.1° | |||
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Identification |
IR | The spectrum should be accord to dexamethasone acetate CRS |
Conform |
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| TLC | The principal spot in the chromatogram obtained with test solution is similar in position and size to the principal spot in the chromatogram obtained with reference solution. |
Conform |
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Related substances |
Maximum single impurity ≤ 0.5 %
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0.23% | |||
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Total impurities≤ 1.0 % |
0.57% | ||||
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Loss on drying |
≤0.50% | 0.10% | |||
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Content |
97.0 percent to 103.0 percent (dried substance) |
99.94% | |||
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Conclusion |
To be conform with EP6.0 |
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Structure:
Pharmacological effects:
Loose pieces
Adrenocortical hormone drugs, its anti-inflammatory, anti-allergic, anti-shock effect is more significant than prednisone, and the water and sodium retention and promote potassium excretion effect is very light, on the pituitary - adrenal inhibition of a strong.
1. Anti-inflammatory effect: this product can reduce and prevent tissue's response to inflammation, thus reducing the expression of inflammation. Hormones inhibit the aggregation of inflammatory cells, including macrophages and leukocytes, at the site of inflammation, and inhibit phagocytosis, release of lysosomal enzymes, and synthesis and release of inflammatory chemical mediators. It can reduce and prevent the tissue's response to inflammation, thereby reducing the appearance of inflammation.
2, immune inhibition: including prevent or inhibit cell-mediated immune response, delayed allergic reaction, reduce T lymphocytes, monocytes, and the number of eosinophilic cells, reduce the immunoglobulin with cell surface receptor binding ability, and inhibit the synthesis and release of interleukin, thereby reducing T lymph cell to cell transformation, and reducing the expansion of the primary immune response. It can reduce the immune complex through the basement membrane and reduce the concentration of complement components and immunoglobulin.
cream
Adrenocortical hormone. This product has anti-inflammatory and anti-allergic effects, can inhibit the proliferation of connective tissue, reduce the permeability of capillary wall and cell membrane, reduce the amount of inflammatory exudation, inhibit the formation and release of histamine and other toxic substances.
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Contact Details
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Tel: 86-15377658509
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