EXE Cas 107868-30-4 Exemestane White Crystal Powder

Product Name: Exemestane
CAS: 107868-30-4
MF: C20H24O2
MW: 296.4
EINECS: 643-090-2

Melting point 155.13°C
Boiling point 453.7±45.0 °C(Predicted)
density 1.13±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥20mg/mL
form powder
color white to off-white

Chemical Properties white to light yellow crystal powder
Uses An antineoplastic (hormonal)
Uses antiinfective
Uses Labeled Exemestane, intended for use as an internal standard for the quantification of Exemestane by GC- or LC-mass spectrometry.

Exemestane is an irreversible steroid aromatase inhibitor. Its structure is similar to that of aromatase’s natural substrate, androstenedione, and acts as a pseudosubstrate. Postmenopausal women’s estrogen is mainly converted from androgen (produced by the adrenal cortex) by aromatase in the surrounding tissue. This drug irreversibly binds with the active site on aromatase to deactivate it, thus dramatically lower estrogen levels in the blood circulation of postmenopausal women. By inhibiting aromatase to lower estrogen levels, it can be used to treat hormone-dependent breast cancer in postmenopausal women.
Exemestane is suitable for treating advanced breast cancer in naturally or artificially postmenopausal women that has not responded well to tamoxifen treatment. It is also suitable for treating estrogen and progesterone receptor positive postmenopausal advanced breast cancer, and it can also be used to treat metastasized breast cancer and as adjuvant therapy for early breast cancer.