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Griseofulvin 126-07-8 Skin Care Raw Materials Effective Against Dermatophytes

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Griseofulvin 126-07-8 Skin Care Raw Materials Effective Against Dermatophytes

Large Image : Griseofulvin 126-07-8 Skin Care Raw Materials Effective Against Dermatophytes Get Best Price

Product Details:

Place of Origin:	China
Brand Name:	DKY
Model Number:	126-07-8

Payment & Shipping Terms:

Minimum Order Quantity:	100g
Packaging Details:	1kg/bag or 25kg/drum
Delivery Time:	5-7 work days
Payment Terms:	T/T, Western Union, MoneyGram
Supply Ability:	1 tons per year

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Detailed Product Description

Cas Number:	126-07-8	Molecular Formula:	C17H19ClO6
Molecular Weight:	354.7822	Density:	1.35 G/cm3
Melting Point:	217 ~ 224℃	Boiling Point:	527.9°C At 760 MmHg
Flash:	205.9 ° C	Vapor Pressure:	3.11E-11mmHg At 25°C
USES:	It Has Inhibition Effect On Various Dermatophytes, And Is Effective On Fungus With Vigorous Growth.	Appearance:	Griseofulvin API Is White Or White Powder; Odorless Or Almost Odorless, Slightly Bitter, Stable To Heat.
High Light:	skin api , skin treatment chemicals

Griseofulvin 126-07-8 skin care raw materials effective against dermatophytes

Basic parameter:

1. Product name: Griseofulvin

2. Product alias: grisovin; 7 - chloro - 2 ', 4, 6 - trimethoxy - 6 - methyl - 3 H, 4 'H - spiro [1 - benzofuran - 2, 1' - cyclohexene] - 3, 4 '- dione.

3. Cas number: 126-07-8, 78739-00-1

4. Molecular formula: C17H19ClO6

5. Molecular weight: 354.7822

6. Density: 1.35 g/cm3

7. Melting point: 217 ~ 224℃

8. Boiling point: 527.9°C at 760 mmHg

9. Flash: 205.9 ° C

10. Vapor pressure: 3.11E-11mmHg at 25°C

11. USES: it has inhibition effect on various dermatophytes, and is effective on fungus with vigorous growth.

12. Appearance: griseofulvin API is white or white powder; Odorless or almost odorless, slightly bitter, stable to heat.

Certificate of Analysis:

Product Name	Griseofulvin		Batch No		20190803
Quantity	500kg		MFG. Date		2019.08.03
Report Date	2019.08.04		Exp Date		2022.08.03
Test Items		Specification		Test Results
Characteristics		A white or yellowish-white, microfine powder		Yellowish-white microfine powder
Melting point		About 220℃		218.6℃~219.4℃
Specific optical rotation		+354°~+364°		+357°
Identification		Meets the requirements		Meets the requirements
Check-up Particles size		Meets the requirements		Meets the requirements
Acidity		0.25g consumed 0.02mol/L NaOH not more than 1.0ml		0.5 ml
Clarity and colour of solution		The solution is clear and not more intensely coloured than reference solution Y₄		clear Y₅-Y₆
Matter soluble in petroleum spirit		≤0.2%		0.1%
Sulphated ash		≤0.2%		0.08%
Related substances		-CL:＜0.60% -H:＜0.15%		-CL:0.37% -H:0.08%
Loss on drying		≤0.5%		0.07%
Abnormal toxicity		Meets the requirements		Meets the requirements
Assay(on the anhydrous substance)		97.0%~102.0%		98.9%
Conclusion		The above certificate of analysis is in compliance with BP2010/EP5, meets the standard requirements.

Structure:

Pharmacological effects:

It can inhibit fungal mitosis, break the spindle structure of mitosis, and stop the metaphase cell division. This product is deposited in the precursor cells of keratin in skin and hair, which can promote keratin resistance to fungal invasion. When infected keratin is shed, replace it with healthy tissue. It is effective against cutaneous fungal infections caused by dermatophytes, microspore and trichoderma, but not against other fungal infections, including candida and bacteria.

Indications:

It is suitable for skin fungal infection caused by dermatophyte, microspore and trichoderma. Clinically, it is mainly used for tinea capitis, severe tinea corporis, tinea imbricata, tinea pedis, etc., which has obvious curative effect on tinea capitis. Some cases may recur, but retreatment can still be effective. It often takes a few months to get an effect, so it is advisable to use other drugs for treatment. Herpes zoster also has a certain therapeutic effect.

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