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Isoniazid 54-85-3 Pharmaceutical Raw Material Used Against Tuberculosis

Isoniazid 54-85-3 Pharmaceutical Raw Material Used Against Tuberculosis

Isoniazid 54-85-3 Pharmaceutical Raw Material Used Against Tuberculosis
Isoniazid 54-85-3 Pharmaceutical Raw Material Used Against Tuberculosis

Large Image :  Isoniazid 54-85-3 Pharmaceutical Raw Material Used Against Tuberculosis Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: 54-85-3

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Packaging Details: 1kg/bag or 25kg/drum or 25kg/bag
Delivery Time: 5-8 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 800 tons per year
Detailed Product Description
CAS Number: 54-85-3 Molecular Formula: C6H7N3O
Molecular Weight: 137.14 EINECS No: 200-214-6
Melting Point: 171-173 ° C Boiling Point: 251.97 ° C
Density: 1.2620 Index Of Refraction: 1.6910
Flash: > 250 ° C Solubility: Soluble In Water (1:10), Soluble In Ethanol (1:50), Insoluble In Ether.
PH: 6-8 (50g/l, H2O, 20℃) Appearance: White Or White-like Crystalline Powder, Odorless, Slightly Sweet And Bitter.
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Isoniazid 54-85-3 pharmaceutical raw material used against tuberculosis


Basic parameter:

1. Product name :Isoniazid
3. CAS number: 54-85-3
4. Molecular formula: C6H7N3O
5. Molecular weight: 137.14
6. EINECS no. : 200-214-6
7. Melting point: 171-173 ° C
8. Boiling point: 251.97 ° C
9. Density: 1.2620
10. Index of refraction: 1.6910
11. Flash: > 250 ° C
12. Storage conditions: Refrigerator
13. Solubility: 125g/l
14. PH: 6-8 (50g/l, H2O, 20℃)
15:Appearance: white or white-like crystalline powder, odorless, slightly sweet and bitter.
16. Solubility: soluble in water (1:10), soluble in ethanol (1:50), insoluble in ether.
Certificate of Analysis:
product name Isoniazid batch no 20190418
manufacture date 2019年04月18日 exp.date 2021年04月
quantity 500Kg analysis date 2019年04月18日
packing 25kg/drum report date 2019年04月20日
standard BP2015
item indicators result
appearance It should be a colorless crystal, or a white to almost white crystalline powder White crystalline powder
melting point should be170-173℃ 171-172℃
(1) (2) chemical reaction should all be positive positive
infrared absorption spectrum The infrared absorption map should be consistent with the control map consistent with the control atlas
pH 6.0~8.0 6.9
Solution clarity and color Meet the regulations conform
Free hydrazine The yellow spot shall not appear on the corresponding position of the front of the main spot of the test product and the hydrazine sulfate spot conform
Dry weight loss ≤0.5% 0.02%
On ignition residue ≤0.1% 0.02%
Heavy metal ≤10ppm conform
assay (C6H7N3O) shall not be less than 99.0% as per dry product 99.5%
conclusion The product was inspected in accordance with BP2015 and the results were in accordance with the regulations.



Isoniazid 54-85-3 Pharmaceutical Raw Material Used Against Tuberculosis 0



1. Biochemical research, as a clinical anti-tuberculosis drug.
2. Anti-tb drug, used for all kinds of tuberculosis
3. It is mainly used for all types of tuberculosis, but also for tuberculous meningitis and other extrapulmonary tuberculosis. It is often used in combination with other anti-tb drugs.
4. The product is used as a high efficiency, low toxicity and cheap anti-tb drug of choice, as well as as an electroplating additive and pharmaceutical intermediate. Isoniazid methane sulfonic acid can be prepared by condensation of nicotinic hydrazine and sodium formaldehyde bisulfite [13447-95-5]. Condensation with formaldehyde to form double isoniazid. This condensation reaction is more soluble, formaldehyde is added to isoniazid aqueous solution, and the reaction can be done at about 65℃ for half an hour. The condensation of isoniazid and vaniloxalic acid was also carried out in aqueous solution, and the reaction temperature was about 95℃ to form isoniazone. These isoniazid derivatives are all anti-tb drugs. Isoniazid class with isoniazid effect is the best, isoniazone on the role of tuberculosis is weaker than isoniazid, but the toxicity of the nervous system and liver is lighter than isoniazid.
5. Isoniazid is highly selective to mycobacterium tuberculosis and has strong antibacterial power. It can inhibit bacteria at a concentration of 0.025 ~ 0.05mg/L in a test tube.
6. Biochemical research. Fluorescence assay of ∆4(4 superscript)-3 steroids by high performance liquid chromatography. The pharmaceutical industry.
7. An antibiotic against tuberculosis that inhibits the biosynthesis of mycotic acid and is a strong DPH metabolic inhibitor. Reversible inhibition of cyp2c19 and cyp3a4, and inactivation of cyp1a2 and cyp2a6.



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