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Isoniazid 54-85-3 Pharmaceutical Raw Material Used Against Tuberculosis
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Detailed Product Description
| CAS Number: | 54-85-3 | Molecular Formula: | C6H7N3O |
|---|---|---|---|
| Molecular Weight: | 137.14 | EINECS No: | 200-214-6 |
| Melting Point: | 171-173 ° C | Boiling Point: | 251.97 ° C |
| Density: | 1.2620 | Index Of Refraction: | 1.6910 |
| Flash: | > 250 ° C | Solubility: | Soluble In Water (1:10), Soluble In Ethanol (1:50), Insoluble In Ether. |
| PH: | 6-8 (50g/l, H2O, 20℃) | Appearance: | White Or White-like Crystalline Powder, Odorless, Slightly Sweet And Bitter. |
| High Light: | raw materials for drugs,pharmaceutical industry raw materials |
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Isoniazid 54-85-3 pharmaceutical raw material used against tuberculosis
Basic parameter:
1. Product name :Isoniazid
2. Product alias: 4-pyridinecarbohydrazide; 4 - PYRIDINECARBOXYLICACIDHYDRAZIDE; AKOSBBS - 00004103; HYCOZID; LABOTEST - BBLT00146690; INAH; ISONICOTINICACIDHYDRAZIDE; ISONIAZIDE
3. CAS number: 54-85-3
4. Molecular formula: C6H7N3O
5. Molecular weight: 137.14
6. EINECS no. : 200-214-6
7. Melting point: 171-173 ° C
8. Boiling point: 251.97 ° C
9. Density: 1.2620
10. Index of refraction: 1.6910
11. Flash: > 250 ° C
12. Storage conditions: Refrigerator
13. Solubility: 125g/l
14. PH: 6-8 (50g/l, H2O, 20℃)
15:Appearance: white or white-like crystalline powder, odorless, slightly sweet and bitter.
16. Solubility: soluble in water (1:10), soluble in ethanol (1:50), insoluble in ether.
Certificate of Analysis:
| product name | Isoniazid | batch no | 20190418 |
| manufacture date | 2019年04月18日 | exp.date | 2021年04月 |
| quantity | 500Kg | analysis date | 2019年04月18日 |
| packing | 25kg/drum | report date | 2019年04月20日 |
| standard | BP2015 | ||
| item | indicators | result | |
| appearance | It should be a colorless crystal, or a white to almost white crystalline powder | White crystalline powder | |
| melting point | should be170-173℃ | 171-172℃ | |
| identify | |||
| (1) (2) chemical reaction | should all be positive | positive | |
| infrared absorption spectrum | The infrared absorption map should be consistent with the control map | consistent with the control atlas | |
| Check | |||
| pH | 6.0~8.0 | 6.9 | |
| Solution clarity and color | Meet the regulations | conform | |
| Free hydrazine | The yellow spot shall not appear on the corresponding position of the front of the main spot of the test product and the hydrazine sulfate spot | conform | |
| Dry weight loss | ≤0.5% | 0.02% | |
| On ignition residue | ≤0.1% | 0.02% | |
| Heavy metal | ≤10ppm | conform | |
| assay | (C6H7N3O) shall not be less than 99.0% as per dry product | 99.5% | |
| conclusion | The product was inspected in accordance with BP2015 and the results were in accordance with the regulations. | ||
Structure:
USES:
1. Biochemical research, as a clinical anti-tuberculosis drug.
2. Anti-tb drug, used for all kinds of tuberculosis
3. It is mainly used for all types of tuberculosis, but also for tuberculous meningitis and other extrapulmonary tuberculosis. It is often used in combination with other anti-tb drugs.
4. The product is used as a high efficiency, low toxicity and cheap anti-tb drug of choice, as well as as an electroplating additive and pharmaceutical intermediate. Isoniazid methane sulfonic acid can be prepared by condensation of nicotinic hydrazine and sodium formaldehyde bisulfite [13447-95-5]. Condensation with formaldehyde to form double isoniazid. This condensation reaction is more soluble, formaldehyde is added to isoniazid aqueous solution, and the reaction can be done at about 65℃ for half an hour. The condensation of isoniazid and vaniloxalic acid was also carried out in aqueous solution, and the reaction temperature was about 95℃ to form isoniazone. These isoniazid derivatives are all anti-tb drugs. Isoniazid class with isoniazid effect is the best, isoniazone on the role of tuberculosis is weaker than isoniazid, but the toxicity of the nervous system and liver is lighter than isoniazid.
5. Isoniazid is highly selective to mycobacterium tuberculosis and has strong antibacterial power. It can inhibit bacteria at a concentration of 0.025 ~ 0.05mg/L in a test tube.
6. Biochemical research. Fluorescence assay of ∆4(4 superscript)-3 steroids by high performance liquid chromatography. The pharmaceutical industry.
7. An antibiotic against tuberculosis that inhibits the biosynthesis of mycotic acid and is a strong DPH metabolic inhibitor. Reversible inhibition of cyp2c19 and cyp3a4, and inactivation of cyp1a2 and cyp2a6.
Contact Details
WuHan Dong Kang Yuan technology co., LTD
Contact Person: Angela
Tel: 86-15377658509
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