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Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity

Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity

Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity
Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity

Large Image :  Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: 79794-75-5

Payment & Shipping Terms:

Minimum Order Quantity: 100g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg per year
Detailed Product Description
CAS No: 79794-75-5 Molecular Formula: C22H23ClN2O2
Molecular Weight: 382.88300 Melting Point: 134-136 ° C
Density: 1.261 G/cm3 Boiling Point: 531.3 Cat 760 MmHg
Flash: 275.1ºC Stability: Stable, But May Be Thermally Sensitive - Refrigerated. Incompatible With Strong Oxidants.
Storage Conditions: 2-8ºC Appearance: White Or White-like Crystalline Powder, Odorless
Solubility: Soluble In Methanol, Ethanol Or Acetone; Slightly Dissolved In 0.1mol/L Hydrochloric Acid Solution; It's Almost Insoluble In Water. Class: Antihistamines.
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raw pharmaceutical materials

Loratadine 79794-75-5 Pharmaceutical Raw Material antihistamines
Basic parameter:
1. Product name: Loratadine
2. Product alias: Claritine; Loranox; CLARATYNE; Doesn; Tadine; Clarityne; Claritine
3. CAS no. : 79794-75-5
4. Molecular formula: C22H23ClN2O2
5. Molecular weight: 382.88300
6. Melting point: 133 ~ 137℃
7. Density: 1.261 g/cm3
8. Melting point: 134-136 ° C
9. Boiling point: 531.3 Cat 760 mmHg
10. Flash: DHS 275.1 C
11. Stability: stable, but may be thermally sensitive - refrigerated. Incompatible with strong oxidants.
12. Storage conditions: 2-8 C
13. Appearance: white or white-like crystalline powder, odorless;
14. Solubility: soluble in methanol, ethanol or acetone; Slightly dissolved in 0.1mol/L hydrochloric acid solution; It's almost insoluble in water.
15. Class: antihistamines.
16. Storage: shading and sealing.
Certificate of Analysis:



batch No.


Mfg. date


Approval Date


Exp. date







White or off white crystalline powder



Freely soluble in acetone,in chloroform,in methanol and in toluene;insoluble in water.



A. By IR absorption, To match with working standard.



B. The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.

Melting Point


132℃~ 137℃

Loss on drying



Residue on ignitio



Related substance


Related compound A

Not Detected

≤ 0.1%

Related compound B

Not Detected

≤ 0.1%

Each individual unknown impurity


≤ 0.1%

Total impurities


≤ 0.3%

Heavy metal



Residual solvent

Not Detected

Isopropyl ether≤0.5%


Not Detected

Ethyl acetate≤0.5%


Not Detected





Conclusion: the material comform to the USP36



Loratadine Pharmaceutical Raw Material 79794-75-5 Antihistamines 99% Purity 0



Pharmacological effects:
Piperidine antihistamines, derivatives of azatadine, selectively antagonize peripheral histamine H1 receptors. Its antihistamine action effect is fast, strong, lasting. Its effect is stronger than astimidazole and terfenadine. This product has no sedative effect and has no anti - muscarinoid choline effect. No enhancement to ethanol. Absorption is rapid and good after oral administration. The peak time of serum concentration tmax was 1.5 hours. The binding rate to plasma protein was 98%. Most of it is metabolized in the liver, and the metabolite decarboxylethoxychloratadine still has antihistamine activity. The product and its metabolites were excreted in urine and feces, and t1/2 lasted about 20 hours. Neither the product nor its metabolites can easily pass the blood-brain barrier, but can appear in milk.
Antihistamine has high selectivity, strong effect and long time for peripheral H1 receptor. It is a long-acting tricyclic antihistamine, which competitively inhibits the histamine H1 receptor and inhibits the allergic symptoms caused by histamine. There was no significant anticholine and central inhibitory effect. Used to relieve symptoms associated with allergic rhinitis, as well as chronic urticaria and other symptoms of allergic skin diseases.

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