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Medicine Grade Pharmaceutical Raw Materials Efavirenz 154598-52-4 Powder

Medicine Grade Pharmaceutical Raw Materials Efavirenz 154598-52-4 Powder

Medicine Grade Pharmaceutical Raw Materials Efavirenz 154598-52-4 Powder
Medicine Grade Pharmaceutical Raw Materials Efavirenz 154598-52-4 Powder

Large Image :  Medicine Grade Pharmaceutical Raw Materials Efavirenz 154598-52-4 Powder Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: $6-9/g
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 3-5work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 100 kgs per year
Detailed Product Description
CAS No: 154598-52-4 Molecular Formula: C14H9ClF3NO2
Molecular Weight: 315.675 Flash: 159.8 ° C
Vapor Pressure: 8.53E-05mmHg At 25°C Melting Point: 139-141 ° C
Specific Rotation: D20-84.7°(c=0.005g/mlinCH3Cl);D25-94.1°(c=0.300inmethanol) Density: 1.53±0.1g/cm3
Storage Conditions: - 20 ° CFreezer Solubility: DMSO: Soluble15mg/mL, The Clear
Appearance: White Or Pink Crystalline Powder
High Light:

raw pharmaceutical materials

,

raw materials for medicines

Good Quality Pharmaceutical Raw Materials Efavirenz 154598-52-4 Low Price Made In China
 
Basic parameter:
1. Product name: EFAVIRENZ
2. Product aliases :(4S) -6-chloro-4 -(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl) -2h-3,1-benzoxazin-2-one; (4 s) - 6 - chloro - 4 - (cyclopropylethynyl) - 4 - (trifluoromethyl) - 1, 4 - dihydro - 2 h - 3, 1 - benzoxazin - two to one
3. CAS no. : 154598-52-4
4. Molecular formula: C14H9ClF3NO2
5. Molecular weight: 315.675
6. Flash: 159.8 ° C
7. Vapor pressure: 8.53E-05mmHg at 25°C
8. Melting point: 139-141 ° C
9. Specific rotation: d20-84.7 °(c=0.005g/mlinCH3Cl); D25-94.1°(c=0.300inmethanol) boiling point: 340.6±42.0° c at 760 mmHg
10. Density: 1.53 + / - 0.1 g/cm3 (Predicted)
11. Storage conditions: - 20 ° CFreezer
12. Solubility: DMSO: soluble15mg/mL, the clear
13. Appearance: white or pink crystalline powder

 
Certificate of Analysis:

Product nameEfavirenzInspection basisUSP
Batch no191011Quantity500KG
Manufacturing date2019.10.11Report date2019.10.12
Inspection itemsstandardInspection results
characterWhite is mostly pink crystalline powder, soluble in methanol, almost insoluble in water.
White crystalline powder
 
Identify
IR identification; The infrared absorption spectrum should be consistent with that of the control sample.
UV identification; The uv absorption spectrum should be consistent with that of the control sample.

 
Conform

solubilityThe sample was completely dissolved in methanol at a concentration of 50mg/ml.Conform
moisture≤0.5%<0.1%
ignition residue≤0.2%<0.1%
Heavy metal≤20ppm<20ppm
isomer≤0.5%<0.04%

Related material
ImpuritiesA
ImpuritiesB
ImpuritiesC,D,E
ImpuritiesF
ImpuritiesG
ImpuritiesH
ImpuritiesI
ImpuritiesJ
ImpuritiesK
ImpuritiesL
ImpuritiesM
ImpuritiesN
ImpuritiesO
ImpuritiesP
Single unknown impurity
Total impurity

 
≤0.15%
≤0.40%
≤0.10%
≤0.15%
≤0.10%
≤0.10%
≤0.25%
≤0.15%
≤0.10%
≤0.10%
≤0.10%
≤0.10%
≤0.10%
≤0.10%
≤0.10%
≤1.0%

 
ND
ND
<0.04%
ND
ND
ND
ND
ND
<0.02%
ND
ND
ND
ND
ND
<0.01%
<0.07%

Content (in terms of anhydrous and solvent-free substances)98.0%-102.0%100.4%
Residual solvent (GC)
ethanol
toluene
tetrahydrofuran
n-hexane

 
≤5000ppm
≤890ppm
≤720ppm
≤290ppm

 
62ppm
ND
ND
ND

conclusion
The product is tested according to the latest USP standard and the result is in accordance with the regulations.

 

Product overview:
Efavirenz is a specific drug against HIV. It is a drug in the NNRTI (non-nucleoside reverse transcriptase inhibitor) class and can be used in highly active anti-retroviral therapy to treat a human immune virus (HIV type 1). First can be used to heal people living with HIV is not treated, she has the advantage of can with lamivudine and zidovudine or tenofovir drugs such as common as more excellent NNRTI - medium (regimen).
Efavirenz is also often used in combination with other drugs to prevent HIV infection and spread among high-risk groups.
 
USES:
1. Used as an antiviral drug. 2. Non-nucleoside reverse transcriptase inhibitors. Used in combination with other viral reverse transcriptase inhibitors for the treatment of hiv-1 infected patients.
 
Efficacy:
Efavirenz is a drug used to fight HIV infection. It is not used alone, but in combination with other drugs to form a compound. The following factors should be taken into account when deciding to start drug treatment: CD4 reading, HIV source load, patient history, resistance and personal willingness.
The initial results of the ACTG5142 trial were published in 2006, which compared efaviron with lopinavir. Efaviron was used in the first-line treatment of various protease inhibitors. ACTG5095 showed the potential of efaviron in maintaining CD4 readings and HIV source loading.
 
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