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Naphazoline Hydrochloride API Intermediates 550-99-2 Used To Treat Rhinitis
Product Details:
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Detailed Product Description
| CAS No: | 550-99-2 | Molecular Formula: | C14H15ClN2 |
|---|---|---|---|
| Molecular Weight: | 246.74 | EINECS No: | 208-989-2 |
| Melting Point: | 254-260 °C | PH: | (50g/l, 25℃) : 4.0 ~ 6.0 |
| Water Solubility: | 170 G/L (20 ºC) | Solubility: | Freely Soluble In Water, Soluble In Ethanol (96 Per Cent). |
| Appearance: | White Or Nearly White Crystalline Powder | Storage: | Low Temperature And Dry To Avoid Light |
| High Light: | pharmaceutical active ingredients,api active pharmaceutical ingredient |
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Naphazoline hydrochloride 550-99-2 API intermediates used to treat rhinitis
Basic parameter:
1. Product name: Naphazolinehydrochloride
2. Product alias :2-(1-naphthalenylmethyl)-4, 5-dihydro-1h-imidazolechloride; Naphconforte; Naphthasoliumchloride; Niazol; Naphthazolinehydrochloride; NAPHAZOLINEHYDROCHLORIDEEXTRAPUREPHEUR, BP, USP. 1 h - Imidazole, 4, 5 - dihydro -, 2 - (1 - naphthalenylmethyl) - monohydrochloride. NAPHAZOLINEHYDROCHLORIDE, USP
3. CAS no. : 550-99-2
4. Molecular formula: C14H15ClN2
5. Molecular weight: 246.74
6. EINECS no. : 208-989-2
7. Melting point: 254-260 °C
8. PH: (50g/l, 25℃) : 4.0 ~ 6.0
9. Water solubility: 170 g/L (20 C)
10. Solubility: Freely soluble in water, soluble in ethanol (96 per cent).
11. Appearance: white or nearly white crystalline powder
Certificate of Analysis:
| Product Name | Naphazoline hydrochloride | Batch No. | 20200419 |
| MFG. Date | 20200419 | Analytical Date | 20200419 |
| Quantity | 500 kg | Standard | EP8.0/USP38 |
| ITEMS | SPECIFICATIONS | RESULTS | |
| Appearance | White crystalline powder | Pass | |
| Assay | 99.00%min` | 99.85% | |
| Melting point | 254.0～260.0℃ | 255.4～258℃ | |
| Loss on drying | 0.50% max | 0.18% | |
| Ph | 5.0～6.5 | 6.2 | |
| Residue on ignition | 0.20% max | 0.09% | |
| Conclusion | Comply with the requirement of standard for BP8.0/USP38 | ||
Structure:
Pharmacological effects:
Hydrochloric acid naphthyl methyl thiazole moiety and nasal eye net, is the hospital otolaryngology and eye commonly used a vasoconstrictor, quasi adrenalin medicine, has the strong contraction of blood vessels and booster effect, has inhibitory effect on the central nervous system, local blood vessels by contracting, in the local lesion of inflammation have anti-inflammatory and analgesic effect, and can eliminate the congestion caused by fatigue or for other reasons. Clinically used for the treatment of cold, acute and chronic rhinitis, allergic conjunctivitis, irritability and inflammatory nasal congestion. Local long-term use will lead to the drug part of the blood flow is too small, resulting in the decline of resistance, resulting in a secondary infection. You can't take it internally. Too much drop or too high concentration of liquid medicine can cause poisoning. Children should be especially cautious, infants, hypertension, hyperthyroidism with caution, atrophic rhinitis is prohibited. The interval between drops should be no less than 4 to 6 hours.
Purpose: this product is a vasoconstrictor. Hypodermic injection of LD50 in rats was 385 mg/kg.
Contact Details
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Contact Person: Angela
Tel: 86-15377658509
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