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Norethindrone 68-22-4 estrogen hormone raw material used for female contraception

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Norethindrone 68-22-4 estrogen hormone raw material used for female contraception

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Product Details:

Place of Origin:	China
Brand Name:	DKY
Model Number:	68-22-4

Payment & Shipping Terms:

Minimum Order Quantity:	10g
Packaging Details:	1kg/bag or 25kg/drum
Delivery Time:	5-7 work days
Payment Terms:	T/T, Western Union, MoneyGram
Supply Ability:	500kg per year

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Detailed Product Description

CAS No:	68-22-4	Molecular Formula:	C20H26O2
Molecular Weight:	298.42	EINECS No:	200-681-6
Melting Point:	205-206 °C	Boiling Point:	379.83 ° C
Specific Rotation:	D20 -31.7° ; D20 -25°	Density:	1.15 G/cm3
Flash:	190.5 ° C	Vapor Pressure:	7.22E-10mmHg At 25°C
Properties:	White Crystalline Powder. Odourless Slightly Bitter	Storage:	The Product Should Be Sealed And Kept In A Cool, Dry Place Away From Light.
Storage Conditions:	- 20 ° C Freezer	Purity:	99%
High Light:	female estrogen raw material , female hormones estrogen

Norethindrone 68-22-4 estrogen hormone raw material used for female contraception

Basic parameter:

1. Product name :Norethindrone

2. Product alias: 17alpha-ethynyl-17-hydroxy-4-estren-3-one; 17 - alpha - ethynyl - 4 - androsten - 17-19 - nor - beta - ol - 3 - one; 17 to 19 - nor alpha - Ethynyl - 4 - androsten - 17 beta - ol - 3 - one; 17 - alpha - ethynyl - 4 - en - 17-19 - norandrost - beta - ol - 3 - one; 17 to 19 - norandrost alpha - Ethynyl - 4 - en - 17 beta - ol - 3 - one; 17 - alpha - ethynyl - 4 - estren - 17 - ol - 3 - one; 17 alpha - Ethynyl - 4 - estren - 17 - ol - 3 - one; 17 - beta - hydroxy - 19 - norpregn - 4 - en - 20 - yn - 3 - one

3. CAS no. : 68-22-4

4. Molecular formula: C20H26O2

5. Molecular weight: 298.42

6. EINECS no. : 200-681-6

7. Melting point: 205-206 °C

8. Boiling point: 379.83 ° C

9. Specific rotation: d20-31.7 °; D20-25 °

10. Density: 1.15 g/cm3

11. Flash: 190.5 ° C

12. Vapor pressure: 7.22E-10mmHg at 25°C

13. Properties: white crystalline powder. Odourless slightly bitter

14. Storage: - 20 ° C Freezer,the product should be sealed and kept in a cool, dry place away from light.

15. Purity: 99%

Certificate of Analysis:

Product Name	Norethisterone	Batch Size	50KG
Manufacturing Date	2020.03.16	Batch No.	20200316
Expiry Date	2023.03.15	Report Date	2020.03.24
Reference Standard	USP36	Packing

TEST	ACCEPTANCE CRITERIONS	RESULTS
Identification	TLC	Positive
	UV spectrum	Positive
	IR spectrum	Positive
Characteristics	White or almost white crystalline powder	conform
Melting point	202 ~ 208℃	202.5~207℃
Loss on drying	≤0.5%	0.23%
Specific rotation	﹣30° ～﹣38°	﹣34.5°
Solution appearance	clear,and free from undissolved solid	Pass
Limit of ethynyl group	8.18%～8.43%	8.27%
Related substanes	total impuritics≤1.5% only one impurity≤0.5%	Pass
Residue on ignition	≤0.1％	Pass
Assay	97.0～103.0％	99.06%

Conclusion

This batch complies with Enterprise standard

Pharmacological effects:

Norethinnes is a derivative of 19-methyltestosterone, an oral progesterone. The activity of progesterone was 4 times higher than that of parneprogesterone, and the activity of estrogen and androgen was weaker. It can inhibit the secretion of hypothalamic luteinizing hormone (LHRH), and stimulate the anterior pituitary to reduce the body's sensitivity to LHRH, so as to block the release of gonadotropin and inhibit ovulation. The peak blood concentration can be reached after 0.5 ~ 4 hours of oral administration, with a half-life of 5 ~ 14 hours. Most of the metabolites are excreted from the body through the kidneys.

USES:

Norethinnes is a 19- methylated testosterone derivative. It is a strong oral progesterone with mild androgen and estrogen activity. It can block the release of gonadotropin, inhibit ovulation and maintain pregnancy. Used for oral contraception, functional uterine bleeding, endometriosis, female infertility, dysmenorrhea, amenorrhea, etc.

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