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Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder

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Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder

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Product Details:

Place of Origin:	China
Brand Name:	DKY
Model Number:	78246-49-8

Payment & Shipping Terms:

Minimum Order Quantity:	1kg
Packaging Details:	1kg/bag or 25kg/drum
Delivery Time:	5-7 work days
Payment Terms:	T/T, Western Union, MoneyGram
Supply Ability:	1000kg per year

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Detailed Product Description

CAS No:	78246-49-8	Molecular Formula:	C19H21ClFNO3
Molecular Weight:	365.83	EINECS No:	616-601-1
Melting Point:	129-131 ° C	Storage Conditions:	- 20 ° C Freezer
Appearance:	White Or Almost White Crystalline Powder, Odorless And Slightly Bitter.	Solubility:	Soluble In Methanol, Dissolved In Ethanol, Slightly Dissolved In Water.
High Light:	pharmaceutical industry raw materials , medicine chemicals

Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder

Basic parameter:

1. Product name :Paroxetinehydrochloride

2. Product alias :3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl) -piperidine hydrochlor; Brl29060a; Brl29060hydrochloride; BRL - 29060; FG - 7051; (3 s - TRANS) - 3 - [(1, 3 - BENZODIOXOL - 5 - YLOXY) METHYL] - 4 - (4 - FLUOROPHENYL) PIPERIDINE; (3 s - trans) - 3 - [(1, 3 - benzodioxol - 5 - yloxy) methyl] - 4 - (4 - fluorophenyl) piperidinehydrochloride; PAROXETINEHCL

3. CAS no. : 78246-49-8

4. Molecular formula: C19H21ClFNO3

5. Molecular weight: 365.83

6. EINECS no. : 616-601-1

7. Melting point: 129-131 ° C

8. Storage conditions: - 20 ° C Freezer

9. Appearance: white or almost white crystalline powder, odorless and slightly bitter.

10. Solubility: soluble in methanol, dissolved in ethanol, slightly dissolved in water.

Certificate of Analysis:

Product Name			Paroxetine hydrochloride hemihydrate
Batch Number			20191222	Quantity	80Kg
Production Site			Paroxetine HCl workshop	Specification	5Kg/tin
Production Date			2019.12.22	Retest Date	2021.12.21
Certificate No.			2019122201	Report Date	2019.12.22
Contents	Specification: EP7.0				Results of analysis
Appearance		White or almost white crystalline powder			Almost white crystalline powder
Identification	Comparing with the spectrum obtained with CRS					Conform
	The principal peak obtained with the test solution is similar in retention and size to that obtained with the reference solution					Conform
	Water (by KF)					Conform
	Reaction of chlorides					Conform
Impurity D		≤0.2%			Did not check out
Related substances		Impurity A: not more than 0.3%				0.03%
		Unspecified impurities: For each impurity, not more than 0.10 %					0.06%
		Total impurities: not more than 0.5%					0.1%
Heavy metals		≤0.002%				＜0.002%
Water		2.2%~2.7%				2.46%
Sulfated ash		≤0.1%				＜0.1%
Assay(anhydrous substance)		97.5%~102.0%				100.2%
Residual solvents		Meets the requirements				Conform
Conclusion: Conforming to EP7.0.

Structure:

Indications:

PX has been shown to improve various types of depression, including obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), panic disorder, social disorder, and post-traumatic stress disorder (PTSD). These include depression with anxiety and reactive depression.

Common depressive symptoms: fatigue, sleep disturbance, lack of interest and pleasure in daily activities, loss of appetite. After satisfactory treatment, continued use of the drug can prevent the recurrence of depression. 【 usage and dosage 】 take it orally, it is recommended to take it at breakfast every day. Swallow the tablet whole without chewing.

For adults: depression and social phobia/social anxiety: the normal dose is 20mg per day. After 2-3 weeks, the dose was increased by 10mg per week, depending on the patient's response. A maximum dose of 50mg per day should be prescribed by the doctor. Obsessive-compulsive neurosis: the normal dose is 40mg/day, the initial dose is 20mg/day, incremented by 10mg/week. The maximum daily dose can be up to 60mg.

Panic disorder: the normal dose is 40mg/day, the initial dose is 10mg/day, increasing by 10mg/week depending on the patient's response, and the maximum daily dose may be up to 50mg/day. The symptoms of panic disorder may worsen early in the treatment, so the initial dose is 10mg. As with all antidepressants, the dosage should be adjusted according to the condition during treatment. Patients should be treated for a long enough period to consolidate the effect, depression should be maintained for at least a few months after recovery, and obsessive-compulsive neurosis and panic disorder should be maintained for a longer period of time. The method of drug withdrawal is similar to that of other psychiatric drugs.

Old people: after taking this product, the blood concentration of the drug is higher than that of adults. For the sake of prudence, the initial dose should be reduced, and the maximum daily dose should not exceed 40mg.

Children: this product is not recommended for children because of incomplete data on its efficacy and safety. Renal/hepatic function impairment patients with severe renal function impairment (creatinine clearance rate < 30ml/ min or more severe liver function impairment >) had higher blood drug concentration after taking this product than healthy people. Therefore, the recommended dose is 20mg per day, and should be limited to the lower limit if additional dose is required.

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