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Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder

Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder

Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder
Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder

Large Image :  Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: 78246-49-8

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg per year
Detailed Product Description
CAS No: 78246-49-8 Molecular Formula: C19H21ClFNO3
Molecular Weight: 365.83 EINECS No: 616-601-1
Melting Point: 129-131 ° C Storage Conditions: - 20 ° C Freezer
Appearance: White Or Almost White Crystalline Powder, Odorless And Slightly Bitter. Solubility: Soluble In Methanol, Dissolved In Ethanol, Slightly Dissolved In Water.
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Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder
Basic parameter:

1. Product name :Paroxetinehydrochloride
2. Product alias :3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl) -piperidine hydrochlor; Brl29060a; Brl29060hydrochloride; BRL - 29060; FG - 7051; (3 s - TRANS) - 3 - [(1, 3 - BENZODIOXOL - 5 - YLOXY) METHYL] - 4 - (4 - FLUOROPHENYL) PIPERIDINE; (3 s - trans) - 3 - [(1, 3 - benzodioxol - 5 - yloxy) methyl] - 4 - (4 - fluorophenyl) piperidinehydrochloride; PAROXETINEHCL
3. CAS no. : 78246-49-8
4. Molecular formula: C19H21ClFNO3
5. Molecular weight: 365.83
6. EINECS no. : 616-601-1
7. Melting point: 129-131 ° C
8. Storage conditions: - 20 ° C Freezer
9. Appearance: white or almost white crystalline powder, odorless and slightly bitter.
10. Solubility: soluble in methanol, dissolved in ethanol, slightly dissolved in water.
Certificate of Analysis:
Product Name Paroxetine hydrochloride hemihydrate
Batch Number20191222Quantity80Kg
Production Site Paroxetine HCl workshopSpecification5Kg/tin
Production Date2019.12.22Retest Date 2021.12.21
Certificate No. 2019122201Report Date 2019.12.22


Specification: EP7.0

Results of analysis


White or almost white crystalline powder

Almost white crystalline powder


  • Comparing with the spectrum obtained with CRS
  • The principal peak obtained with the test solution is similar in retention and size to that obtained with the reference solution
  • Water (by KF) 
  • Reaction of chlorides 

Impurity D

≤0.2%Did not check out

Related substances

  • Impurity A: not more than 0.3%
  • Unspecified impurities: For each impurity, not more than 0.10 %
  • Total impurities: not more than 0.5%

Heavy metals




Sulfated ash


Assay(anhydrous substance)


Residual solvents

Meets the requirements

Conclusion: Conforming to EP7.0. 

Paroxetine hydrochloride 78246-49-8 Medicine Raw Material antidepressant powder 0

PX has been shown to improve various types of depression, including obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), panic disorder, social disorder, and post-traumatic stress disorder (PTSD). These include depression with anxiety and reactive depression.
Common depressive symptoms: fatigue, sleep disturbance, lack of interest and pleasure in daily activities, loss of appetite. After satisfactory treatment, continued use of the drug can prevent the recurrence of depression. 【 usage and dosage 】 take it orally, it is recommended to take it at breakfast every day. Swallow the tablet whole without chewing.
For adults: depression and social phobia/social anxiety: the normal dose is 20mg per day. After 2-3 weeks, the dose was increased by 10mg per week, depending on the patient's response. A maximum dose of 50mg per day should be prescribed by the doctor. Obsessive-compulsive neurosis: the normal dose is 40mg/day, the initial dose is 20mg/day, incremented by 10mg/week. The maximum daily dose can be up to 60mg.
Panic disorder: the normal dose is 40mg/day, the initial dose is 10mg/day, increasing by 10mg/week depending on the patient's response, and the maximum daily dose may be up to 50mg/day. The symptoms of panic disorder may worsen early in the treatment, so the initial dose is 10mg. As with all antidepressants, the dosage should be adjusted according to the condition during treatment. Patients should be treated for a long enough period to consolidate the effect, depression should be maintained for at least a few months after recovery, and obsessive-compulsive neurosis and panic disorder should be maintained for a longer period of time. The method of drug withdrawal is similar to that of other psychiatric drugs.
Old people: after taking this product, the blood concentration of the drug is higher than that of adults. For the sake of prudence, the initial dose should be reduced, and the maximum daily dose should not exceed 40mg.
Children: this product is not recommended for children because of incomplete data on its efficacy and safety. Renal/hepatic function impairment patients with severe renal function impairment (creatinine clearance rate < 30ml/ min or more severe liver function impairment >) had higher blood drug concentration after taking this product than healthy people. Therefore, the recommended dose is 20mg per day, and should be limited to the lower limit if additional dose is required.
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