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Pharmaceutical Raw Materials Thiamine Hydrochloride 67-03-8 API Intermediates

Pharmaceutical Raw Materials Thiamine Hydrochloride 67-03-8 API Intermediates

Pharmaceutical Raw Materials Thiamine Hydrochloride 67-03-8 API Intermediates
Pharmaceutical Raw Materials Thiamine Hydrochloride 67-03-8 API Intermediates

Large Image :  Pharmaceutical Raw Materials Thiamine Hydrochloride 67-03-8 API Intermediates Get Best Price

Product Details:

Place of Origin: China
Brand Name: DKY
Model Number: A7038

Payment & Shipping Terms:

Minimum Order Quantity: 1kg
Packaging Details: 1kg/bag or 25kg/drum
Delivery Time: 5-7 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 50 tons per year
Detailed Product Description
CAS No: 67-03-8 EINECS No: 200-641-8
Molecular Formula: C12H17ClN4OS·HCl Molecular Weight: 337.27
Melting Point: 246-250 ℃ Density: 1.3766
Refractive Index: 1.6000 Flash Point: 9 ° C
Storage Conditions: 2-8 ° C Solubility H2O: 0.1 G / Ml At 20 ° C, Clear, Colorless
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Pharmaceutical Raw Materials Thiamine Hydrochloride 67-03-8 API


Basic parameter:

1. Product Name: thiamine hydrochloride

2. Chemical name: 3 - [(4-amino-2-methyl-5-pyrimidinyl) methyl] - 5 - (2-hydroxyethyl) - 4-methylthiazolium chloride

3. CAS No.: 67-03-8

4. EINECS No.: 200-641-8

5. Molecular formula: c12h17cln4os · HCl

6. Molecular weight: 337.27

7. Melting point: 246-250 ℃

8. Density: 1.3766

9. Refractive index: 1.6000

10. Flash point: 9 ° C

11. Storage conditions: 2-8 ° C

12. Solubility H2O: 0.1 g / ml at 20 ° C, clear, colorless

13. Properties: white acicular crystal powder, weak smell similar to rice bran, bitter taste, water free dry products in the air quickly absorb water (4%). It is stable to heat (170 ℃), soluble in water and slightly melted in ethanol. Insoluble in benzene and ether.


Certificate of Analysis:

Product name Vitamin B1(hydrochloride) Number 20190625
Weight 1000 kg Manufacturing date Jun 25, 2019
Batch no 20190625 Effective date Jun 24, 2021
project USP36 Result
Appearence White crystalline or crystalline powder White crystalline powder
identification positive positive
Absorption coefficient 406~436 413
PH PH:2.8-3.3 3.0
clarity ≤0.5Standard turbidimetric liquid Conform
solution color ≤0.1ml Potassium dichromate colorimetric solution Conform
sulfate ≤0.01% Conform
nitrate ≤0.25% Conform
Dry weight loss ≤5.0% 3.7%
On ignition residue ≤0.1% 0.04%
Fe ≤0.002% Conform
Heavy metal ≤10 PPm Conform
Cl 20.6%~21.2% 20.6%
Assay ≥99.0% 99.75%
Conclusion: This product complies with the 36 th edition of the United States pharmacopoeia.
Pharmaceutical Raw Materials Thiamine Hydrochloride 67-03-8 API Intermediates 0



1. Biochemical research, fluorescence and phosphorescence analysis of phosphorus, clinical medicine belongs to vitamin B group, used for prevention of beriberi, treatment of multiple neuritis, central nervous system injury and other diseases.

Use this product plays an important role in sugar metabolism. The energy of nerve tissue is mainly supplied by glycogenesis and metabolism. Once vitamin B1 is deficient, the energy supply is blocked, and lactic acid pyruvate accumulates, resulting in multiple neuritis, which shows abnormal sensation, weakness of limbs, neuralgia and atrophy of muscles. At the same time, the metabolism of heart muscle is maladjusted, and there are symptoms of cardiac insufficiency such as palpitation, chest distress, cardiac hypertrophy, blood stasis of liver and surrounding edema. The mild deficiency of vitamin B1 indicates anorexia, weight loss and weakness. It is used for vitamin B1 deficiency, hyperthermia, hyperthyroidism, large amount of glucose input, systemic infection, diabetes and polyneuritis. According to the health standard for the use of food nutritional fortifiers (1993) issued by the Ministry of health of China, vitamin B1 can be used in cereals, products and drinks with a dosage of 3-5mg / kg, and also in infant food. The dosage is 4-8 mg / kg. Oral toxicity of ld507700-15000 mg / kg in mice.


2. Thiamine hydrochloride is a form of vitamin B1. Its application is nutritional supplement. Vitamin B1 is involved in the intermediate metabolism of sugars in the body. The deficiency of vitamin B1, the decrease of cocarboxylase activity and the obstruction of glucose metabolism affect the whole metabolism process. The decarboxylation of acetone was blocked, it could not enter into the cycle of tricarboxylic acid, and it did not continue to oxidize and accumulated in the tissue. At this time, there is insufficient energy supply to the nerve tissue, so corresponding neuromuscular symptoms can appear, such as multiple neuritis, muscle atrophy and edema, and in serious cases, it can also affect the function of the heart muscle and brain tissue. Vitamin B1 deficiency can also cause indigestion, anorexia and constipation.



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