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Ethynylestradiol 57-63-6 powder For Women's Health
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Detailed Product Description
| CAS Number: | 57-63-6 | Molecular Formula: | C20H24O2 |
|---|---|---|---|
| Molecular Weight: | 296.4 | EINECS No: | 200-342-2 |
| Density: | 1.21 G/cm3 | Melting Point: | 182-183 ℃ |
| Boiling Point: | 457.2°C At 760 MmHg | Flash: | 211.2 ° C |
| Steam Pressure: | 3.74E-09mmHg At 25°C | Storage Conditions: | - 20 ° C Freezer |
| Refractive Index: | -30 ° (C=0.4, Pyridine) | Content: | 97.0% ~ 103.0%. |
| Solubility: | Soluble In Ethanol, Propanol, Ether, Chloroform, Dioxane, Vegetable Oil And Sodium Hydroxide Solution, Almost Insoluble In Water. No Smell. | Appearance: | White Or White-like Crystalline Powder; Odourless |
| High Light: | female estrogen raw material,women hormones estrogen |
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Ethynylestradiol 57-63-6 estrogen hormone raw material for women's health
Basic parameter:
1. Product name :Ethynylestradiol
2. Product name :Etacrynic; 19 -,3,5 NORPREGNA - 1 (10) -- TRIEN - 20 - YNE - 3 ALPHA - DIOL in 2; 19 - NOR - 1,3,5 [10], 17 to 20 - alpha - PREGNATRIEN YNE - 3 in 2 - DIOL; 1,3,5 (10) -- ESTRATRIEN - 17 - ALPHA - ETHYNYL - 3 - BETA - 12 DIOL; ACETENYLESTRADIOL; (17 - alpha) - 19 -,3,5 norpregna - 1 (10) -- trien - 20 - yne - 3, 12 diol. 17 - alpha - ethinyl - 17 - beta - estradiol; 17 alpha - Ethinyl - 17 beta - estradiol
3. The CAS number: 57-63-6
4. Molecular formula: C20H24O2
5. Molecular weight: 296.4
6. EINECS no. : 200-342-2
7. Density: 1.21 g/cm3
8. Melting point: 182-183 ℃
9. Boiling point: 457.2°C at 760 mmHg
10. Flash: 211.2 ° C
11. Steam pressure: 3.74E-09mmHg at 25°C
12. Storage conditions: - 20 ° C Freezer
13. Refractive index: -30 ° (C=0.4, Pyridine)
14. Content: 97.0% ~ 103.0%.
15. Solubility: ethanol: 50 mg/mL, clear, modest yellow
16. Appearance: white or white-like crystalline powder; odourless
17. Storage conditions: - 20 ° C Freezer
18. Solubility: soluble in ethanol, propanol, ether, chloroform, dioxane, vegetable oil and sodium hydroxide solution, almost insoluble in water. No smell.
Certificate of Analysis:
| Product Name | Ethinyl Estradiol | Batch Size | 0.05kg |
| Manufacturing Date | 2019.07.05 | Batch No. | 20190705 |
| Expiry Date | 2023.07.04 | Report Date | 2019.07.10 |
| Reference Standard | USP38 | Packing |
| TEST | Specifications | RESULTS |
| Identification | TLC | Positive |
| UV spectrum | Positive | |
| UV spectrum | Positive | |
| Characteristics | White to creamy white, odorless,crystalline powder. | conform |
| Solubility | Soluble in alcohol, in chloroform, in ether, in vegetable oils, and in solutions of fixed alkali hydroxides; insoluble in water. | conform |
| Completeness of solution | Dissolve 100 mg in 5 mL of alcohol; the solution is clear and free from undissolved solid. | conform |
| Melting point | 180~ 186℃ | 181.6~ 183.2℃ |
| Specific optical rotation | - 28°~ -29.5° | -28.3° |
| Loss on drying | ≤1.0% | 0.38% |
| Content | 97.0 ~ 102.0% | 99.32% |
| Residual Solvents | acetone≤5000ppm | 102ppm |
| Conclusion | This batch complies with USP38 |
Structure:
Pharmacological effects:
Ethinylestradiol has positive and negative feedback effects on hypothalamus and pituitary gland, and can stimulate gonadotropin secretion in small doses. The large dosage suppresses its secrete, the ovulation that suppresses ovarian thereby, achieve anti-fertility effect. It stimulates the pituitary gland to synthesize and release gonadotropins (FSH and LH), which in turn stimulates the gonads to release sex hormones. Hypothalamus secretion of gonadotropin-releasing hormone is regulated by a variety of factors, including circulating sex hormones. Single dose can increase the circulation of sex hormones; Continuous use can down-regulate the gonadotropin releasing receptor in adenohypophysis, thus reducing the secretion of sex hormones.
Indications:
Supplementation of estrogen deficiency, treatment of female gonadal dysfunction, amenorrhea, menopause syndrome, etc. For the treatment of advanced breast cancer (postmenopausal women) and advanced prostate cancer; It can be used in combination with gestational hormone drugs to inhibit ovulation and can be used as contraceptives. It is mainly used to inhibit ovulation in clinic. Also used in children with cryptorchidism androgen excess, pituitary tumor. It can be used to diagnose hypothalamic-adenohypophysia-gonadal dysfunction according to the changes of gonadotropin and gonadotropin levels.
Treatment of amenorrhea and infertility caused by hypogonadal gonadotropin secretion, multiple follicular ovarian infertility. For amenorrhea associated with weight loss, diet should be used first to correct weight. It is also used for prostate cancer (often with ciproprogesterone or fluoroformimide), delayed or early puberty, and endometriosis. Mainly used to inhibit ovarian ovulation, to achieve the purpose of contraception.
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