Estrone API Powder Medical USP Standard 1 Kg Aluminum Foil Bag Packing

Chemical Properties Crystalline Solid

Chemical Properties Estrone is an odorless white crystalline powder.

Uses A metabolite of 17β-Estradiol.

Uses estrogen

Uses A metabolite of 17-Estradiol

Definition ChEBI: A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.

 

General Description Estrone, 3-hydroxyestra-1,3,5(10)-trien-17-one, is less active than estradiol but more active than itsmetabolite, estriol. As the salt of its 3-sulfate ester, estroneis the primary ingredient in conjugated estrogens, USP, andesterified estrogens, USP. Although originally obtainedfrom the urine of pregnant mares (about 10 mg/L), estroneis now prepared synthetically. Estrone itself is not availablein commercial oral formulations, but can be obtained at compounding pharmacies as a topical formulation. Oleoylestrone,the C3 ester of estrone with oleic acid, is in phase IIclinical trials for the treatment of obesity. This acyl estronederivative reduces fat stores by a mechanism not involvingthe ER, although some of the oleoyl-estrone is hydrolyzedto estrone in vivo.

 

 

 

White plate-like crystalline or crystalline powder. Stable in air. Mp256-262 ℃; Than the polarimetric [alpha] 25 d + + 168 ° 158 ° - (dioxane), [alpha] 22 d + 152 ° (0.995%, chloroform); The ethanol solution has the maximum absorption at the wavelength of 287nm. Almost insoluble in water, soluble in dioxane, pyridine, and base hydroxide solutions, slightly soluble in ethanol (1:400), acetone, benzene, chloroform, ether, and vegetable oils.

 

 

 

 

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