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Calcipotriene Skin Care Raw Materials Cas 112828-00-9 For Psoriasis Treatment
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Detailed Product Description
| CAS No: | 112828-00-9 | Molecular Formula: | C27H40O3 |
|---|---|---|---|
| Molecular Weight: | 412.6 | EINECS No: | 686-849-3 |
| Flash: | 250.6ºC | Boiling Point: | 582ºC At 760 MmHg |
| Density: | 1.12 G/cm3 | Melting Point: | 166-168 ℃ |
| Appearance: | White To Almost White Powder | ||
| High Light: | skin api,skin treatment chemicals |
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Calcipotriene skin care raw materials 112828-00-9 for the treatment of psoriasis
Basic parameter:
1. Product name :Calcipotriene
2. Product names (1 r, 3 s, 5 z) - 5 - [(2 E) - 2 - [(1 r, 7 ar) - 1 - [(E, 2 r, 5 s) - 5 - cyclopropyl - 5 - hydroxypent - 3 - en - 2 - yl] - 7 - a 2 - methyl - filling a, 5, 6 - h - inden hexahydro - 1-4 - ylidene) ethylidene] - 4 - methylenecyclohexane - 1, 3 - diol; (1 r, 3 s, 5 z) - 5 - (2 - [(4 e) - 1 - [(2 r, 3 e, 5 r) - 5 - CYCLOPROPYL - 5 - HYDROXYPENT - 3 - EN - 2 - YL] - 7 a - METHYL - HEXAHYDRO - 1 h - IN; Calcipotrien; CALCIPOTRIOL; (1 s, 3 s, 5 z) - 5 - [(2 e) - 2 - [(1 r, 3 ar, 7 ar) - 1 - [(e, 2 s) - 5 - CYCLOPROPYL - 5 - hydroxy - pent - 3 - en - 2-7 a - methyl - 2 - yl] filling a, 5, 6 - h - inden hexahydro - 1-4 - ylidene] ethylidene] - 4 - methylidene - cyclohexane - 1, 3 - diol, (1 r, 3 s, 5 z) - 5 - [(2 e) - 2 - [1 - [(e, 2 r, 5 r) - 5 - cyclopropyl - 5 - hydroxypent - 3 - en - 2 - yl] - 7 a - methyl - 2 filling A, 5, 6 - h - inden hexahydro - 1-4 - ylidene] ethylidene] - 4 - methylidenecyclohexane - 1, 3 - diol; 24 - CYCLOPROPYL - (1 alpha, beta 3, 5 z, e, e, and 24 s) - 9 - SECOCHOLA - 5,7,10 (19), 22 -,3,24 TETRAENE - 1 - TRIOL; Calcipotriene
3. CAS no. : 112828-00-9
4. Molecular formula: C27H40O3
5. Molecular weight :412.6EINECS :686-849-3
6. Flash: DHS 250.6 C
7. Boiling point :582 C at 760 mmHg
8. Density: 1.12 g/cm3
9. Melting point: 166-168 ℃
10. Appearance: white to almost white powder
Certificate of Analysis:
| Product Name: Calcipotriol | Batch No.: 191201 |
| Batch Size: 17g | Manufacturing Date:Dec. 01, 2019 |
| Ref. Standard: EP7.0 | Report Date: Dec. 01, 2019 |
| Items | Spcifications | Results |
| Appearance | White or almost white crystalline powder | Conforms |
| Identification | ||
| a) IR |
IR chromatograph Conforms to the characteristic peak of R.S. |
Conforms |
| b) HPLC |
chromatogram Conforms to the characteristic peak of R.S. |
Conforms |
| Related substances | ||
| Known impurity | ||
| Impurity B((7Z)-calcipotriol) | Not more than 0.5% | ND |
| Impurity C((5E)-calcipotriol) | Not more than 1.0% | 0.19% |
| Impurity D (24-epi-calcipotriol) | Not more than 1.0% | 0.33% |
| Any other impurity | Not more than 0.1% | ND |
| Total impurities | Not more than 2.5% | 0.50% |
| LOD | Not more than 1.0% | 0.35% |
| Solvent residue | ||
| Acetone | Not more than0.5% | 0.25% |
| Tetrahydrofuran | Not more than0.072% | ND |
| Ethyl acetate | Not more than0.5% | 0.15% |
| Methanol | Not more than0.3% | 0.132% |
| Toluene | Not more than0.089% | ND |
| Ethanol | Not more than0.5% | 0.11% |
| Assay | 95.5~102.0% | 99.1% |
| Conclusion:It conforms to the Enterprise Standard | ||
| Storage: Store in a -20 ℃, keep sealed and kept from light. | ||
| Shelf Life: 2years | ||
Structure:
Summary:
Capotriol is a derivative of vitamin D. It regulates the synthesis of DNA and keratin in cells by binding with VD3 receptors on the cell surface. It can inhibit the hyperproliferation and differentiation of skin cells (keratinocytes), thus causing the abnormal proliferation and differentiation of psoriatic skin cells to be corrected by. At the same time, it regulates the release of inflammatory cytokines, inhibits inflammatory infiltration and proliferation, and plays an anti-inflammatory role. For the scalp and other special parts of the psoriasis treatment effect is better.
USES:
Capotril is one of the most effective non - glucocorticoid drugs in the treatment of localized psoriasis.
Contact Details
WuHan Dong Kang Yuan technology co., LTD
Contact Person: Angela
Tel: 86-15377658509
Send your inquiry directly to us
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